Changes of coagulation function and other indicators of the thawed FFP and FLP at 2-6℃
Objective To observe the changes of coagulation factor activity and protein content of the thawed fresh fro-zen plasma(FFP)and fresh liquid plasma(FLP)during storage at 2-6℃,and to provide reference for exploring the ap-propriate storage time of FFP at 2-6℃after thawing.Methods The small-thaw group and the large-thaw group were re-spectively detected for the activity of coagulation factor FⅤ(FⅤ∶C)and FⅧ(FⅧ∶C),and the levels of fibrinogen(Fib),total protein(TP)and albumin(Alb)in TTP at 1,2,3,4,5,6 and 7 days after thawing.And the FLP was de-tected for FⅤ∶C,FⅧ∶C,Fib,TP and Alb at 1,2,3,4,5,6,7 days and 1,6,11,16,21,26 and 31 days after prep-aration,respectively.Results In FFP group,FⅧ∶C decreased gradually with the prolongation of storage time after melting(P<0.05),and decreased by 37.4%and 47.6%respectively in the two groups on the 7th day.There was no statistical difference in FⅤ∶C,Fib,TP and Alb(P>0.05).In FLP group,FⅧ∶C decreased gradually with the prolongation of stor-age time after melting(P<0.05).There was no statistical difference in FⅤ∶C in 7-day storage group(P>0.05),but it de-creased gradually in 31-day storage group(P<0.05).There was no statistical difference in Fib,TP and Alb(P>0.05).Conclusion Although FⅧ∶C is decreased in thawed FFP stored at 2-6℃for 7 days,it is still about 52.4%,which should be able to play a normal role in clinical practice.
万方数据
维普
