Objective To analyze the clinical outcomes of a patient with thrombotic thrombocytopenic purpura(TTP)as the starting performance who was considered as systemic lupus erythematosus(SLE)under multiple abnormal autoantibod-ies,and summarize the treatment experience through the clinical outcomes of plasma exchange combined with high-does ster-oid pulse therapy.Methods A middle-aged female patient presented with initial symptoms of fever,bleeding and hemolytic thrombocytopenia.Laboratory tests showed decreased activity of thrombospondin type 1 motif no.13(ADAMT13)and abnor-mal autoantibodies.The diagnosis was considered SLE with TTP,and the patient underwent continuous plasma exchange combined with high-dose steroid pulse therapy.The patient's platelet recovery was dynamically observed.Results The pa-tient responded well to plasma exchange combined with high-does steroid pulse therapy,with platelet count raising to normal in a short period of time and hormone gradually decreasing.There was no recurrence during the follow-up period.Conclu-sion TTP combined with lupus is not common,but when both occur simultaneously,plasma exchange combined with high-does steroid pulse therapy may effectively alleviate symptoms.This treatment approach can serve as a valuable reference for similar clinical cases.
维普
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