首页|积极应对HIV抗病毒治疗对血液安全的潜在影响

积极应对HIV抗病毒治疗对血液安全的潜在影响

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HIV感染和传播严重威胁民众健康和公共卫生安全,抗逆转录病毒治疗(ART),包括暴露前预防(PrEP)和暴露后预防(PEP),对控制AIDS病情和遏制HIV传播发挥了巨大作用。由于ART后HIV感染者血浆病毒载量和抗原水平下降,血液筛查相关实验标记物的生成和检测可能受到影响。国内外已发现正在接受ART的献血者,且有增加趋势,献血者HIV筛查的不确定性和风险性正在增加,采供血机构应高度重视,积极采取相关研究,探讨科学合理的应对措施。
Addressing blood safety implications of donors using HIV antiretroviral therapy
HIV infection and transmission is a serious threat to people's health and public health security.Antiretroviral therapy(ART),including pre-exposure prophylaxis(PrEP)and post-exposure prophylaxis(PEP),has played a huge role in controlling AIDS and curbing HIV transmission.However,the production and detection of HIV screening test markers may be affected because of the decrease of plasma viral loads and antigen levels in HIV-infected individuals after ART.It has been found that blood donors are receiving ART,and there is an increasing trend of it amongst blood donor population at home and abroad.Therefore,the uncertainty and risk of HIV screening of blood donors are increasing.In this case,blood collection and supply institutions should attach great importance to it,and take relevant studies and explore scientific and reasonable countermeasures actively.

blood safetyantiretroviral therapy(ART)blood donorHIV/AIDS

杨忠思、戴梓宁、王同显

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青岛市中心血站,山东青岛 266071

血液安全 抗逆转录病毒治疗 献血者 HIV/AIDS

2024

中国输血杂志
中国输血协会 中国医学科学院输血研究所

中国输血杂志

CSTPCD
影响因子:1.279
ISSN:1004-549X
年,卷(期):2024.37(10)