Comparison of centrifugal-membrane hybrid plasmapheresis and centrifugation therapeutic plasma exchange in hyperlipidemia
Objective To establish a new centrifugal-membrane hybrid plasmapheresis (CMHP) model,and observe its clinical efficacy,safety and advantages in the treatment of hyperlipidemia by comparing with centrifugation therapeutic plasma exchange (cTPE). Methods A retrospective analysis was performed on 47 patients with hyperlipidemia treated in our department from August 2021 to September 2023,with a total of 60 treatments. They were divided into two groups:CM-HP group with 37 patients and 46 treatments;cTPE group included 10 patients with 14 treatments. In the CMHP group,the plasma was separated by a blood cell separator and the plasma components were separated by a two-stage membrane plasma component separator. In the cTPE group,the plasma was separated by a blood cell separator for therapeutic plasma ex-change. The clinical efficacy,safety and advantages of the two groups were compared. Results The reduction ratios of to-tal cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein choles-terol (LDL-C) before and after treatment in CMHP group were 68. 56％[59. 81％,73. 42％],65. 80％[55. 55％,75.98％]and 46.57％[36.02％,54.83％]and 66.67％[43.48％,76.24％]respectively,with statistically significant difference (P<0.001). The decrease ratios of TC,TG and HDL-C before and after treatment in cTPE group were 42.52％[29.67％,49.85％],52.32％[38.43％,67.07％]and 22.36％[8.51％,33.65％],respectively,and the difference was statistically significant (P<0.05).The plasma treatment multiple was 1.48 (0.29) in CMHP group,which was signifi-cantly higher than 0.87 (0.26) in cTPE group,with a statistically significant difference (P<0.001),resulting in higher TC and HDL-C reduction ratios in CMHP group than in cTPE group,with a statistically significant difference (P<0.001),while there was no significant difference in TG reduction rate between the two groups (P>0.05). At the same time,the cTPE group required 1520.00 mL[1462.50 mL,2000.00 mL]plasma input,while the CMHP group achieved zero blood input. The adverse reaction ratio was 6.52％(3/46) in CMHP group and 7.14％(1/14) in cTPE group,and the difference was not statistically significant (P>0.05). Conclusion Compared with cTPE,CMHP can better reduce blood lipid levels without any blood products,avoid the spread of blood infectious diseases,and have a low incidence of adverse reactions,so it has a good clinical application prospect.
万方数据
维普
