Objective To analyze the production of platelet antibodies in children with congenital heart disease,identi-fy the types of antibodies,and explore their effects on platelet count,coagulation function and platelet function. Methods A retrospective analysis was conducted on 3504 congenital heart disease patients without a history of blood transfusion who were treated at Beijing Children's Hospital between January 2019 and June 2024 to study the positive rate of platelet antibod-ies. Platelet antibody types were detected using the solid-phase agglutination method,and the platelet count and coagulation function of the children were analyzed. The impact of platelet antibodies on platelet function was evaluated using a coagula-tion and platelet function analyzer. Results The positive rate of platelet antibody in children with congenital heart disease with no history of blood transfusion was 9.7％ (341/3504),higher than the overall positive rate of 6.6％ (2657/40311) in the general pediatric population. The platelet antibodies in congenital heart disease cases with positive platelet antibodies were mainly autoantibodies. There was no significant difference in platelet count between antibody-positive children and an-tibody-negative children. However,the prothrombin time(s) of antibody-positive children was significantly longer than that of antibody-negative children[(12.19±1.07) vs (11.32±0.77)]. Platelets sensitized by antibodies showed a significant reduction in function compared to non-sensitized platelets. Conclusion Children with congenital heart disease have a high rate of positivity for autoantibodies,which are associated with abnormalities in coagulation function and can lead to reduced platelet function.
关键词
先天性心脏病/血小板抗体/凝血功能/血小板功能
Key words
congenital heart disease/platelet antibodies/coagulation/platelet function
维普
万方数据