Distribution characteristics of blood group antigen and susceptibility in patients with pulmonary tuberculosis
Objective To investigate the distribution characteristics and susceptibility of ABO and Rh blood group anti-gens in patients with pulmonary tuberculosis in Xinjiang,so as to provide a theoretical basis for the prevention and treatment of tuberculosis. Methods The clinical information of hospitalized patients with pulmonary tuberculosis from different ethnic groups (n=32508,infection group) and healthy people (n=15442,control group) in the Eighth Affiliated Hospital of Xin-jiang Medical University and the First Affiliated Hospital of Xinjiang Medical University from 2014 to 2020 was collected,and the frequency distribution of ABO and Rh blood group antigens in the two groups was analyzed retrospectively. Results 1) The constituent ratios of pulmonary tuberculosis prevalence in Uygur,Han,HaKazak and Hui people were 51.11％,33.66％,9.09％ and 6.13％ respectively,with significant difference (P<0.001). The prevalence rate of pulmonary tuber-culosis in females (52.65％) was higher than in males (47. 35％)(P<0. 05). 2) The frequency of type B antigen was highest at 30.10％,and the frequency of type AB antigen was the lowest at 10.09％ in pulmonary tuberculosis group;The distribution of blood types was B type>O type>A type>AB type. In the control group,the distribution of blood types was O type>A type>B type>AB type. The frequency of type B in Uighur,type O in Kazak,type A in Hui and Han nationalities in the infection group was higher than that in the control group (P<0.001);3)The distribution of blood type among patients with pulmonary tuberculosis in different ethnic groups was Uygur B>A>O>AB,Kazak O>B>A>AB,Hui A>O=B>AB,Han A>B>O>AB,with significant difference between different ethnic groups(P<0.001). 4)The total positive rate of RhD blood group among pulmonary tuberculosis patients was 97.26％,while the negative rate was 2.74％. Among them,the Uyghur ethnicity has the highest frequency at 4.44％,followed by Kazakh at 2.13％,Hui at 1.26％,Han at 0.58％,with signifi-cant differences(P<0.05). Conclusion The proportion of pulmonary tuberculosis prevalence among Uygur,Han,HaKa-zak and Hui people were 51.11％,33.66％,9.09％ and 6.13％,respectively. The distribution frequency of blood type was B>O>A>AB. Moreover,higher frequencies of tuberculosis in Uygur with type B,Kazak with type O,Hui with type A and Han with type A suggest that these blood types may be susceptible risk factors for pulmonary tuberculosis,which pro-vides new insights for the prevention and control of pulmonary tuberculosis.
万方数据
维普
