首页|特异区段替换小鼠性发育表型的研究

特异区段替换小鼠性发育表型的研究

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
目的 了解性发育相关数量性状基因座(quantitative trait locus,QTL)(DXMit68-rs29053133)在近交系小鼠A/J和C3H/HeJ(C3H)中是否存在影响表型的序列差异,以帮助对候选基因进行筛选.方法 利用A/J和C3H构建了针对该区段的特异区段替换系小鼠,并对其雌鼠的性发育相关性状进行研究.结果 A/J和C3H在这一QTL中染色体的序列差异,没有引起相关性状的明显差异.结论 研究结果显示,A/J和C3H小鼠中该QTL区段中存在序列差异的基因并不是引起性发育表型产生差异的候选基因.
Pubertal phenotype in interval-specific congenic mouse strains
Objective To screen the candidate genes of a puberty-relevant quantitative trait locus ( QTL) ( DXMit68-rs29053133 ) via detecting the sequence differences and pubertal phenotype between the inbred mouse strains A/J and C3H/HeJ( C3H ) . Methods To construct the interval specific congenic strains from A/J and C3H mice,and identify the pubertal phenotype of the female mice. Results The chromosomal sequence differences between A/J and C3H mice did not influence the pubertal phenotype significantly. Conclusion The candidate genes in the QTL showing sequence differences are not directly related with the puberty phenotypic differences between A/J and C3H mouse strains.

Interval-specific congenic strains, micePubertyPhenotypesSequence differences

张婷婷、仝莉、肖君华、李凯、周宇荀

展开 >

东华大学生物科学与技术研究所,上海201620

特异区段替换小鼠 性发育 表型 序列差异

国家自然科学基金上海市科委"实验动物专项基金"

3107109011040900200

2013

10.3969/j.issn.1005-4847.2013.02.001

中国实验动物学报
中国实验动物学会，中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCDCSCD
影响因子：0.767
ISSN：1005-4847
年,卷(期)：2013.21(2)
  • 1
  • 4