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特发性肺纤维化实验模型研究进展

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特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种慢性、进行性、间质性肺疾病,发病率逐年上升,死亡率高,预后极差.目前,IPF发病机制仍不明确,治疗措施有限.实验模型是深入研究IPF发病机制和探索有效防治措施的关键工具,近年来其造模方式已得到不断的发展和优化,鉴于此,本研究对近年来IPF实验模型的构建方法和研究进展进行总结,以期为临床前研究选择合适实验模型提供思路和参考.
Research progress on experimental models of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis(IPF)is a chronic,progressive interstitial lung disease.IPF incidence is increasing yearly with high mortality and poor prognoses.At present,IPF pathogenesis remains unclear,and its treatments are limited.The experimental model is important to further study IPF pathogenesis and explore effective preventive and therapeutic measures.In recent years,its modeling method have been continuously developed and optimized.This study summarizes the establishment method and research progress of IPF experimental models in recent years to provide ideas and references for preclinical research to select appropriate experimental models.

idiopathic pulmonary fibrosisacute exacerbationexperimental modeltraditional Chinese medicine model

李智慧、余学庆、杨曙光、于宁霞、臧丹阳

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河南中医药大学,郑州 450046

河南中医药大学第一附属医院,郑州 450000

特发性肺纤维化 急性加重 实验模型 中医模型

国家自然科学基金河南省自然科学基金河南省中医药科学研究专项

821743072323004202762022JDZX118

2024

中国实验动物学报
中国实验动物学会,中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCD北大核心
影响因子:0.767
ISSN:1005-4847
年,卷(期):2024.32(1)
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