中国实验动物学报2024,Vol.32Issue(1) :128-138.DOI:10.3969/j.issn.1005-4847.2024.01.015

基于物理方法的皮肤创伤动物模型构建及评价指标研究进展

Research progress on the construction and evaluation indicators of skin-wound animal models based on physical methods

欧雪 余志杰 何瑶 郑晓媛
中国实验动物学报2024,Vol.32Issue(1) :128-138.DOI:10.3969/j.issn.1005-4847.2024.01.015

基于物理方法的皮肤创伤动物模型构建及评价指标研究进展

Research progress on the construction and evaluation indicators of skin-wound animal models based on physical methods

欧雪 1余志杰 2何瑶 2郑晓媛2
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作者信息

  • 1. 重庆大学医学院,重庆 400030
  • 2. 重庆市第四人民医院,重庆市急救医疗中心药剂科,重庆 400014
  • 折叠

摘要

皮肤创伤已成为全球性公共问题,尤其是慢性伤口的难愈合严重影响了患者的健康生活.目前,物理方法构建皮肤创伤动物模型是研究皮肤创面的主要方法,而不同的皮肤创伤动物模型其生物学特点不同.因此,本文通过检索Pubmed、中国知网近5年与皮肤创伤动物模型构建的相关资料,以小鼠、大鼠、其他动物的皮肤创伤模型进行分类,总结并分析了基于物理方法的皮肤创伤动物模型的构建方法及评价指标,并评价不同动物模型的优缺点,旨在对皮肤创伤动物模型的合理构建及药物的研究开发提供思路.

Abstract

Skin wounds are global public problems,especially in terms of the difficult healing of chronic wounds,which may seriously affect patients'lives.Most skin-wound animal models are currently established by physical method,and different animal models have different biological characteristics.This review therefore classifies mouse,rat,and other animal models of skin wounds according to the literature,summarizes and analyzes the construction of skin-wound animal models based on physical method and evaluation indicators,and considers the advantages and disadvantages of different animal models,to provide a basis for the rational construction of skin-wound animal models and drug research and development.

关键词

物理方法/皮肤创伤/模型构建/评价指标

Key words

physical method/skin wounds/construction of models/evaluation indicators

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基金项目

重庆市临床药学重点专科建设项目(渝卫办发[2023]2)

出版年

2024
中国实验动物学报
中国实验动物学会,中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCDCSCD北大核心
影响因子:0.767
ISSN:1005-4847
参考文献量66
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