脾虚证实验动物模型构建及评价方法的研究述评
Construction of experimental animal models and evaluation of spleen deficiency syndrome:a review
张永龙 1马唯刚 1钱星羽 1赵素红 1李姗姗 1郭永明 2徐枝芳 2潘兴芳 2邱继文 3郭义 4李忠正2
作者信息
- 1. 天津中医药大学实验针灸学研究中心,天津 301617
- 2. 天津中医药大学实验针灸学研究中心,天津 301617;天津中医药大学针灸推拿学院,天津 301617
- 3. 天津中医药大学实验针灸学研究中心,天津 301617;天津中医药大学医学技术学院,天津 301617
- 4. 天津中医药大学实验针灸学研究中心,天津 301617;天津中医药大学,天津 301617
- 折叠
摘要
中医症候实验动物模型的构建在中医药作用机理研究方面起到重要支撑作用,近年来脾虚证动物模型的构建和评价文献报道越来越多,但是构建方法标准不一,评价指标客观化不足,本文将从动物选取、模型建立、宏观表征、行为学实验、脾虚的客观指标等方面总结脾虚动物模型的构建和评价方法,以期为脾虚证实验动物模型的构建提供理论指导,为脾虚动物模型平台的选取提供文献参考.
Abstract
The construction of experimental animal models plays an important supporting role in research into the mechanisms of action of Chinese medicines.There have been increasing reports of the construction and evaluation of animal models of spleen deficiency;however,the construction method have involved different standards and there has been insufficient objectification of the evaluation indexes.In this review,we summarize the construction and evaluation method of animal models of spleen deficiency from the aspects of animal selection,model establishment,macroscopic characterization,behavioral experiments,and objective indexes of spleen deficiency,with a view to providing theoretical guidance for the construction of experimental animal models of spleen deficiency and references for the selection of animal model platforms for spleen deficiency.
关键词
脾虚证/动物模型/评价方法/综述Key words
spleen deficiency/animal models/evaluation methods/review引用本文复制引用
基金项目
国家自然科学基金面上项目(82174524)
出版年
2024
国家科技期刊平台
NSTL
万方数据