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脾虚证实验动物模型构建及评价方法的研究述评

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中医症候实验动物模型的构建在中医药作用机理研究方面起到重要支撑作用,近年来脾虚证动物模型的构建和评价文献报道越来越多,但是构建方法标准不一,评价指标客观化不足,本文将从动物选取、模型建立、宏观表征、行为学实验、脾虚的客观指标等方面总结脾虚动物模型的构建和评价方法,以期为脾虚证实验动物模型的构建提供理论指导,为脾虚动物模型平台的选取提供文献参考。
Construction of experimental animal models and evaluation of spleen deficiency syndrome:a review
The construction of experimental animal models plays an important supporting role in research into the mechanisms of action of Chinese medicines.There have been increasing reports of the construction and evaluation of animal models of spleen deficiency;however,the construction method have involved different standards and there has been insufficient objectification of the evaluation indexes.In this review,we summarize the construction and evaluation method of animal models of spleen deficiency from the aspects of animal selection,model establishment,macroscopic characterization,behavioral experiments,and objective indexes of spleen deficiency,with a view to providing theoretical guidance for the construction of experimental animal models of spleen deficiency and references for the selection of animal model platforms for spleen deficiency.

spleen deficiencyanimal modelsevaluation methodsreview

张永龙、马唯刚、钱星羽、赵素红、李姗姗、郭永明、徐枝芳、潘兴芳、邱继文、郭义、李忠正

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天津中医药大学实验针灸学研究中心,天津 301617

天津中医药大学针灸推拿学院,天津 301617

天津中医药大学医学技术学院,天津 301617

天津中医药大学,天津 301617

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脾虚证 动物模型 评价方法 综述

国家自然科学基金面上项目

82174524

2024

中国实验动物学报
中国实验动物学会,中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCD北大核心
影响因子:0.767
ISSN:1005-4847
年,卷(期):2024.32(3)