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愤怒大鼠实验模型概述

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愤怒这一负面情绪会对人体产生诸多影响。与愤怒情绪产生有关的脑部区域主要与中央灰质、杏仁核、下丘脑有关。近些年关于愤怒动物模型的研究逐渐增多,愤怒机制的研究也不断深入。关于愤怒模型的研究大部分集中在中缝背核、下丘脑和海马区域,相关的神经递质研究主要与GABA的表达和单胺类神经递质含量相关。本文通过检索愤怒有关的动物模型,总结愤怒发生的脑内神经机制,旨在为愤怒情绪的研究提供参考借鉴。
Overview of experimental rat models of anger
Anger is a negative emotion that can have many effects on the body.The brain regions associated with the production of anger are mainly related to the central gray matter,amygdala,and hypothalamus.There has recently been a gradual increase in research into relevant animal models and the mechanisms of anger.Most studies of anger models have focused on the mid-suture dorsal nucleus,hypothalamus,and hippocampal regions,and related neurotransmitter studies have mainly been related to GABA expression and monoamine neurotransmitter content.This review summarizes the neural mechanisms of anger in the brain based on animal models related to anger,with the aim of providing a reference for the study of angry emotions.

angeranimal modelhypothalamusprefrontal areahippocampus

张春鹏、颜嘉宏、张永华

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浙江中医药大学附属杭州市中医院,杭州 310007

愤怒 动物模型 下丘脑 前额区 海马

中医药现代化专项

2020zx013

2024

中国实验动物学报
中国实验动物学会,中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCD北大核心
影响因子:0.767
ISSN:1005-4847
年,卷(期):2024.32(3)