肠纤维化动物模型研究进展
Advances in animal models of intestinal fibrosis
王玺 1刘浩 2沈鑫宇 2孙心 3邹得方 4顾任钧5
作者信息
- 1. 南京中医药大学第一临床医学院,南京 210023
- 2. 东部战区总医院门诊部,南京 210002
- 3. 江苏省中医院消化科,南京 210004
- 4. 南京中医药大学药学院,南京 210023
- 5. 南京中医药大学中医学院,南京 210023;东部战区总医院消化科,南京 210002
- 折叠
摘要
肠纤维化(intestinal fibrosis,IF)是炎症性肠病(inflammatory bowel disease,IBD)的并发症之一,其难愈性和复发性给患者带来了严重的负担.目前该发病机制尚不明确,且尚无有效治疗方法,故造模研究备受关注,但现缺乏公认的动物模型.本文就国内外肠纤维化动物模型的建立方法、适用范围、关键特征和优缺点,从造模周期和造模方式两个维度做一综述.
Abstract
Intestinal fibrosis is a complication of inflammatory bowel disease,and its refractory and recurrent nature impose a serious disease burden on patients.The disease's pathogenes is not clear,and there is no effective treatment.Moreover,there is still a lack of recognized intestinal fibrosis models.In this paper,we review the method used to establish animal models of intestinal fibrosis both at home and abroad,and consider the clinical relevance,key characteristics,and advantages and disadvantages of the procedures.Intestinal fibrosis models were summarized according to the modeling period and method.
关键词
肠纤维化/动物模型/模型特点Key words
intestinal fibrosis/animal model/model characteristic引用本文复制引用
基金项目
江苏省中医药科技发展计划青年人才项目(QN202206)
南京中医药大学罗林秀教师发展基金(LLX202310)
出版年
2024
国家科技期刊平台
NSTL
万方数据