Analysis of animal models of sequelae of pelvic inflammatory disease based on data mining
王玉超 1张兵 2潘静 2李雅琳 2于潇 3刘金星2
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作者信息
1. 山东中医药大学附属医院,济南 250014;山东中医药大学,济南 250014
2. 山东中医药大学,济南 250014
3. 山东中医药大学附属医院,济南 250014
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摘要
目的 梳理盆腔炎性疾病后遗症(sequelae of pelvic inflammatory disease,SPID)动物模型特点,为规范造模流程、提高成模率提供参考.方法 检索近40年有关SPID动物模型的文献,总结并分析动物种类、造模方法、阳性对照药、评价指标等.结果 纳入243篇文献,多采用苯酚胶浆法或微生物感染法诱导大鼠建立SPID模型,造模周期在14～16 d为主,大多以盆腔组织形态观察和苏木素-伊红(HE)染色判定模型成功与否.中医病症结合模型研究较少.结论 SPID动物模型造模方法缺乏一致性的判定标准,建议综合动物行为学变化、盆腔组织形态学改变以及病理等进行评价.同时,中医证候造模缺乏有效的方法和评价标准,有待进一步研究发展.
Abstract
Objective To review the characteristics of animal models of sequelae of pelvic inflammatory disease(SPID)to provide a reference for standardizing the modeling process and improving the modeling rate.Methods Literature relevant to animal models of SPID from the past 40 years was searched,and animal species,modeling method,modeling cycles,modeling substances,positive control drugs,and evaluation indexes were summarized and analyzed.Results A total of 243 study manuscripts were included,most of which induced the SPID model in rats via the phenol paste or microbial infection method.The modeling cycles were typically between 14 and 16 days,and the success of the models was mostly determined by pelvic tissue morphology observation and pathological HE staining.Few research reports have focused on the traditional Chinese medicine(TCM)disease combination model.Conclusions No consistent criteria have been established for SPID animal model modeling,and thus it is recommended that researchers evaluate changes to animal behavior,pelvic histomorphology,and pathology.TCM syndrome modeling lacks effective method and evaluation standards,which need further research and development.Finally,the selection and use of positive-control drugs need to be further explored and perfected.
关键词
盆腔炎性疾病后遗症/数据挖掘/动物模型
Key words
sequelae of pelvic inflammatory disease(SPID)/data mining/animal model
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