首页|坏死性凋亡在胰腺疾病中的作用机制研究进展

坏死性凋亡在胰腺疾病中的作用机制研究进展

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坏死性凋亡介于细胞凋亡和坏死之间,是一种受调控的天冬氨酸特异性半胱氨酸蛋白酶非依赖性程序性细胞死亡,可诱导炎症反应发生.研究表明,它与胰腺疾病的病程进展及预后密切相关,在胰腺疾病进展中发挥重要的双向调控作用,且相关的坏死性凋亡抑制剂与诱导剂有望用于胰腺疾病的治疗.基于此,本文对坏死性凋亡发生的机制及其在胰腺疾病进展中的作用进行综述,旨在为胰腺疾病的发病机制和治疗提供新的认识,为其靶向性药物的研发提供理论依据.
Research progress on mechanism of necrotizing apoptosis in pancreatic disease
Necroptosis is a regulated process of programmed cell death independent of aspartic acid-specific cysteine protease,which can induce inflammation.Studies have shown that necroptosis is closely related to the progression and prognosis of pancreatic disease and plays an important two-way regulatory role in its progression.Related necroptosis inhibitors and inducers are expected to be used in the treatment of pancreatic disease.We herein review the mechanism of necroptosis and its role in the progression of pancreatic disease to provide a new understanding of the pathogenesis and treatment of pancreatic diseases and offer a theoretical basis for the research and development of targeted drugs.

necroptosisacute pancreatitispancreatic cancerreceptor-interacting protein kinase 1(RIPK1)receptor-interacting protein kinase 3(RIPK3)mixed-lineage kinase domain-like(MLKL)

杨润泽、秦靖、郭晨博、胡耀华、汪湛东、张延英、宋冰、白敏、师长宏、汪永锋

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甘肃中医药大学基础医学院,兰州 730000

空军军医大学实验动物中心,西安 710000

延安大学医学院,陕西延安 716000

坏死性凋亡 急性胰腺炎 胰腺癌 受体相互作用蛋白激酶1 受体相互作用蛋白激酶3 混合谱系激酶结构域样

国家自然科学基金甘肃省自然科学基金甘肃省中医药管理局项目

8216087122JR5RA591GZKZ-2021-10

2024

10.3969/j.issn.1005-4847.2024.07.012

中国实验动物学报
中国实验动物学会，中国医学科学院医学实验动物研究所

中国实验动物学报

CSTPCD北大核心
影响因子：0.767
ISSN：1005-4847
年,卷(期)：2024.32(7)
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