Mechanism of leukemia stem cells immune escape by Traditional Chinese Medicine intervention
章美玲 1崔亚茹 1陈抒鹏 1罗钧允 1曾英坚2
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作者信息
1. 江西中医药大学,南昌 330000
2. 江西中医药大学,南昌 330000;江西中医药大学附属医院,南昌 330000
折叠
摘要
白血病是目前临床上高发的急危重症,病死率极高,其中白血病干细胞(leukemia stem cells,LSC)发生免疫逃逸是白血病诱导缓解后复发及进展的主要因素.中医药(Traditional Chinese Medicine,TCM)临床诊疗具有鲜明的辨证论治优势,基于"以平为期"的诊治目的,中医药辨治白血病强调恢复人体机能的"阴阳和谐",有助于提高机体自身免疫力,符合干预肿瘤细胞免疫逃逸的机制.本文从文献研究及中医理论探讨中医药干预LSC免疫逃逸的机制及其研究进展.
Abstract
Leukemia is a critical disease with a high incidence and extremely high fatality rate.Immune escape by leukemia stem cells(LSC)is the main factor for recurrence and progression after remission.Clinical diagnosis and treatment by Traditional Chinese Medicine(TCM)have distinct advantages of syndrome differentiation and treatment.Based on the purpose of diagnosis and treatment,leukemia treatment by TCM emphasizes the harmony of yin and yang to restore human functions,which is conducive to improve autoimmunity and conforms to the mechanism of intervention for tumor cell immune escape.This article discusses the mechanism and research progress of TCM interventions in LSC immune escape based on literature and TCM theory.
关键词
中医药/白血病细胞/免疫逃逸/干预机制
Key words
Traditional Chinese Medicine/leukemic cells/immune escape/intervention mechanism
维普
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