中国比较医学杂志2024,Vol.34Issue(3) :127-132.DOI:10.3969/j.issn.1671-7856.2024.03.016

TRP通道介导线粒体功能调控及其与心血管疾病关系研究进展

Progress of research into mitochondria functional regulation by transent receptor potential channels and its relevance to cardiovascular diseases

朱美萍 张世忠
中国比较医学杂志2024,Vol.34Issue(3) :127-132.DOI:10.3969/j.issn.1671-7856.2024.03.016

TRP通道介导线粒体功能调控及其与心血管疾病关系研究进展

Progress of research into mitochondria functional regulation by transent receptor potential channels and its relevance to cardiovascular diseases

朱美萍 1张世忠1
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作者信息

  • 1. 三峡大学国家中医药管理局中药药理科研三级实验室,三峡大学基础医学院,湖北宜昌 443000
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摘要

瞬时受体电位(transient receptor potential,TRP)通道是一类非选择性阳离子通道.近年来研究发现TRP通道与多种疾病有关,其中关于TRP通道通过线粒体功能调控参与相关心血管疾病机制的研究,正成为心血管疾病机制研究的热点之一.目前相关的文献主要集中在TRPV、TRPM和TRPC.本文主要就上述3种TRP通道在线粒体功能调节中的作用及其与心血管疾病的关系研究进展进行综述.

Abstract

Transent receptor potential(TRP)channels are non-selective cation channels.In recent years,a large number of studies have found that TRP channels participate in a variety of cardiovascular diseases.How mitochondrial function is regulated by TRP channels and the relationship to cardiovascular diseases have become research hotspots.Up to now,related studies have mainly focused on TRPV,TRPM,and TRPC channels.This review focuses on the roles of the above TRP channels in the regulation of mitochondrial function and their relationships to cardiovascular diseases.

关键词

TRP通道/线粒体功能/心血管疾病

Key words

TRP channel/mitochondria function/cardiovascular disease

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基金项目

国家自然科学基金(30872716)

出版年

2024
中国比较医学杂志
中国实验动物学会,中国医学科学院医学实验动物研究所

中国比较医学杂志

CSTPCD北大核心
影响因子:0.473
ISSN:1671-7856
参考文献量52
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