NF-κB信号通路介导巨噬细胞参与心肌缺血再灌注损伤的研究进展
Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway
李世龙 1王贺 1曹英杰1
作者信息
- 1. 河南中医药大学第一附属医院,心脏中心/国家区域(中医)心血管诊疗中心,郑州 450000
- 折叠
摘要
心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)已经成为影响心血管疾病患者临床转归的最严重并发症之一,巨噬细胞的免疫炎症反应与MIRI的发生发展密切相关.目前已有多项研究表明,通过影响巨噬细胞的极化和炎症状态、焦亡、浸润等功能,NF-κB信号通路可参与MIRI调节,是MIRI治疗的潜在靶点.因此,本文将对巨噬细胞功能与MIRI调节作用之间的NF-κB信号通路研究进展进行综述.
Abstract
Myocardial ischemia reperfusion injury(MIRI)has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases.The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI.Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages,pyrodeath,infiltration and other functions,and is a potential target for MIRI therapy.Therefore,this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.
关键词
心肌缺血再灌注损伤/巨噬细胞/NF-κB通路Key words
myocardial ischemia reperfusion injury/macrophage/NF-κB pathway引用本文复制引用
基金项目
国家自然科学基金(82274316)
河南省中医药科学研究专项(2019JDZX2071)
河南省中医药科学研究专项(2022JDZX037)
出版年
2024
国家科技期刊平台
NSTL
万方数据