糖代谢重编程在阿尔茨海默病发病机制中的研究进展
Advances in the study of glucose metabolic reprogramming in the pathogenesis of Alzheimer's disease
许倩 1杨琼 2谭子虎3
作者信息
- 1. 湖北中医药大学中医临床学院,武汉 430061
- 2. 湖北中医药大学中医临床学院,武汉 430061;湖北中医药大学附属医院/湖北省中医院/湖北省中医药研究院老年病科,武汉 430061
- 3. 湖北中医药大学附属医院/湖北省中医院/湖北省中医药研究院老年病科,武汉 430061
- 折叠
摘要
阿尔茨海默病(Alzheimer's disease,AD)是以全面性痴呆为特征的神经退行性疾病.尽管AD的发病机制已历经半个世纪的广泛研究,但与AD相关的细胞损伤和认知缺陷的基础机制仍然难以明确.目前,多项研究证实AD中存在神经细胞葡萄糖代谢模式的改变,且存在显著的区域差异.这种转变是细胞存活和疾病进展的关键,甚至先于病理改变和认知功能障碍数十年出现.本文综述了不同类型神经细胞以及不同脑区糖代谢重编程导致AD的潜在机制,以及他们之间的相互影响,以期为AD的研究夯实基础,为开发新的防治方法提供线索和思路.
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by widespread dementia.Despite the extensive research conducted on the pathogenesis of AD over the past 50 years,the underlying mechanisms responsible for AD-related cellular damage and cognitive impairment remain elusive.Multiple studies have confirmed alterations in the glucose metabolism patterns occur within the nerve cells of individuals with AD.This metabolic transition plays a crucial role in cell survival and disease progression,occurring decades before pathological changes and cognitive dysfunction even manifest.This article provides an overview of the potential mechanisms through which glucose metabolism reprogramming contributes to AD development in various types of nerve cells and brain regions,as well as the implication of their interplay.We aim to establish a foundation for further investigations into AD while offering insights and ideas for the development of novel preventive and therapeutic approaches.
关键词
阿尔茨海默病/神经细胞/葡萄糖代谢重编程/研究进展Key words
Alzheimer's disease/nerve cells/glucose metabolic reprogramming/research progress引用本文复制引用
基金项目
湖北省自然科学基金联合基金重点项目(2022CFD022)
湖北省自然科学基金联合基金青年项目(2022CFD143)
湖北省自然科学基金联合基金青年项目(2022CDF144)
出版年
2024
国家科技期刊平台
NSTL
万方数据