Notch信号通路在肝纤维化中的研究进展
Progress of research into Notch signaling pathway in liver fibrosis
纪少秀 1张恒耀 1张媛 1文莉2
作者信息
- 1. 宁夏医科大学附属银川市中医医院,银川 750001
- 2. 成都中医药大学基础医学院,成都 611137
- 折叠
摘要
肝纤维化是慢性肝病向肝硬化甚至肝癌发展的必经病理过程.肝纤维化发生是一个高度整合的、动态的病理过程,是诸多细胞相互串扰以及细胞因子彼此作用的结果.Notch信号通路是一种进化上保守的细胞间信号传导机制,在调节多细胞动物发育和组织更新方面发挥重要作用.越来越多的研究表明Notch信号通路通过多种途径参与肝纤维化形成.本研究旨在综述Notch信号通路在肝纤维化形成中的作用,以期为肝纤维化临床及基础研究提供参考.
Abstract
Liver fibrosis is a key pathological process in the progression of chronic liver disease to cirrhosis and even liver cancer.The occurrence of liver fibrosis is a highly integrated and dynamic pathological process result ing from the interactions of many cells and cytokines.The Notch signaling pathway is an evolutionarily conserved intercellular signal transduction mechanism that plays important roles in regulating the development and tissue renewal of multicellular animals.Multiple studies have shown that Notch signal transduction participates in the formation of liver fibrosis in a variety of ways.Therefore,this paper reviews the role of Notch signaling in cells involved in the formation of liver fibrosis to explain the function of this signaling pathway in liver fibrosis.
关键词
Notch信号通路/肝纤维化/综述Key words
Notch signaling pathway/liver fibrosis/review引用本文复制引用
基金项目
国家自然科学基金(82104569)
四川省科技厅应用基础研究项目(2021YJ0253)
成都中医药大学"十四五""基础增厚"行动计划团队(242022007)
出版年
2024
国家科技期刊平台
NSTL
万方数据