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铁死亡在脑缺血再灌注损伤机制中的研究进展

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铁死亡是近年来新发现的一种细胞死亡方式,参与了多种病理生理过程,如缺血再灌注(ischemia/reperfusion,I/R)损伤、神经退行性疾病、肿瘤等.缺血性脑卒中(ischemia stroke,IS)目前在世界范围内缺乏有效防治手段,而铁死亡参与脑缺血再灌注损伤(cerebral ischemia reperfusion injoury,CIRI)过程,为治疗IS提供了希望.文章通过检索PubMed、万方、维普及CNKI等数据库近年来发表的相关文献后纳入50篇文章,从铁代谢、铁死亡的概念、机制和调控、铁死亡在CIRI机制中的作用以及抑制铁死亡的方法等方面入手,为探讨通过抑制铁死亡寻找潜在治疗IS的新策略的可能性提供参考.
Research progress of ferroptosis in the mechanism of cerebral ischemia reperfusion injury
Ferroptosis is a newly cell death mode discovered in recent years,involving in a variety of pathophysiological processes,such as ischemia reperfusion injury,neurodegenerative diseases and tumors,etc.At present,there is a lack of effective method to prevent and treat ischemic stroke worldwide,and ferroptosis which is involved in cerebral ischemia reperfusion injury.50 articles were included in this paper after searching the related literature,which published in databases such as PubMed,Wanfang,VIP and CNKI in recent years.Discussing the iron metabolism and the concept,mechanism and regulation of ferroptosis,the role of ferroptosis in the mechanism of cerebral ischemia reperfusion injury,and the method of inhibiting ferroptosis,this paper attempts to provide reference for finding a new potential treatment for ischemic stroke from the direction of inhibiting ferroptosis.

ferroptosisiorn metabolismischemia strokereperfusion injury

蒋欢、白文娅、邵建林

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昆明医科大学第一附属医院麻醉科,昆明 650000

铁死亡 铁代谢 缺血性脑卒中 再灌注损伤

国家自然科学基金云南省科技计划昆医联合专项重点项目

81960250202201AY070001-037

2024

中国比较医学杂志
中国实验动物学会,中国医学科学院医学实验动物研究所

中国比较医学杂志

CSTPCD北大核心
影响因子:0.473
ISSN:1671-7856
年,卷(期):2024.34(7)