首页|基于中西医临床病证特点的动脉粥样硬化动物模型分析

基于中西医临床病证特点的动脉粥样硬化动物模型分析

扫码查看
原文链接
  • 万方数据
  • 维普
对常见动脉粥样硬化(AS)动物模型与中西医临床病证特点进行吻合度分析与评分,为研究AS疾病选择的动物模型提供参考.对常见AS动物模型的品种、造模方法、原理、特点进行总结,并根据AS中西医临床诊断标准对 15 种常见模型进行吻合度分析.现有AS动物模型常用的制备方法有高脂喂养型、机械损伤联合高脂喂养型、基因工程联合高脂喂养型、化学诱导结合高脂喂养型以及病证结合模型.其中,中西医临床吻合度相对较高的是球囊损伤联合高脂喂养型、ApoE-/-联合高脂喂养型以及病证结合中的痰瘀互结型.现有的AS动物模型大多以西医造模方法为主,评价标准亦以西医诊断指标为主,缺少中西医病证结合的特点,很难揭示中医整体观念、辨证论治的核心.因此,构建准确、高吻合度的中西医病证结合动物模型将是深入研究AS机制和防治的重点.
Animal model analysis of atherosclerosis based on clinical symptoms in traditional Chinese medicine and Western medicine
On the basis of the clinical characteristics of atherosclerosis(AS)in traditional Chinese medicine(TCM)and Western medicine,this paper analyzes common animal models of AS.The coincidence of clinical characteristics of the models was scored in the hope of providing new ideas and a reference for those studying AS.This paper reviews the varieties,modeling method,modeling principles,and characteristics of common animal models of AS.Moreover,similarities among common animal models,in terms of their clinical diagnostic criteria and symptom characteristics,were assessed.High-fat feeding type,mechanical injury combined with high-fat feeding type,genetic engineering combined with high-fat feeding type,chemical induction combined with high-fat feeding type,and combined Chinese clinical syndrome and Western disease AS models are widely established.Comparative analysis showed that balloon injury combined with high fat feeding type,ApoE receptor-knockout mouse combined with high-fat diet type,and phlegm and blood stasis type models of disease and symptom combinations showed a comparatively high level of clinical agreement between Chinese and Western medicine.Presently,most animal models of AS have a high degree of relevance to Western medicine,and the evaluation criteria used for the models are predominately from a Western medicine perspective.Models that combine disease and syndrome are lacking,hindering the development of wholism concepts and treatment through the differentiation of syndromes used in TCM.Therefore,establishing an animal model with a high degree of accuracy and coincidence between TCM and Western perspectives that combines the disease and its TCM symptoms is a top priority for studying the prevention and treatment of AS.

atherosclerosiscombination between disease and syndromediagnostic criteriaanimal modelscoincidence degree

罗诗雯、罗权烨、聂娟、李鎏、韦晶玥、陈惠卿、朴美虹、杨冬梅

展开 >

湖南中医药大学中西医结合防治血管疾病基础研究中心,长沙 410208

湖南中医药大学湘产大宗药材品质评价湖南省重点实验室,长沙 410208

动脉粥样硬化 病证结合 诊断标准 动物模型 吻合度

国家自然科学基金湖南省科技创新计划资助湖南省科技厅重点项目湖南省教育厅重点项目湖南省自然科学基金项目湖南省教育厅项目湖南省大学生创新创业训练计划项目湖南中医药大学重点培育学科

816737222021RC40642022SK201120A3792022JJ4031422B0387S202210541021202302

2024

10.3969/j.issn.1671-7856.2024.08.014

中国比较医学杂志
中国实验动物学会，中国医学科学院医学实验动物研究所

中国比较医学杂志

CSTPCD北大核心
影响因子：0.473
ISSN：1671-7856
年,卷(期)：2024.34(8)
  • 40