首页|基于中西医临床病证特点的强直性脊柱炎动物模型分析

基于中西医临床病证特点的强直性脊柱炎动物模型分析

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强直性脊柱炎(ankylosing spondylitis,AS)是一种以骶髂关节炎、脊柱关节炎为主要表现的自身免疫性疾病。该病好发于青壮年男性,致残率高,严重威胁患者生命健康。临床常用的治疗药物中生物制剂价格昂贵,激素、非甾体抗炎药、抗风湿药不良反应多。中医药可调节免疫、抗炎,临床疗效佳。为了深入研究强直性脊柱炎的发病机理和治疗药物、方法的研发及筛选,本文总结了现有强直性脊柱炎动物模型造模方法、机制及分析模型优缺点,对动物模型的中西医病证特点进行对比,评价中西医病证吻合度。构建中西医病证吻合度更高的强直性脊柱炎动物模型是中医药治疗强直性脊柱炎的关键。本文分析动物模型中西医病证吻合度,以期为强直性脊柱炎的中药研发、针灸治疗等中医疗法奠定基础。
Analysis of ankylosing spondylitis animal model based on clinical characteristics of traditional Chinese and Western medicine
Ankylosing spondylitis is an autoimmune disease with sacroiliac arthritis and spinal arthritis as the main manifestations.The disease mainly occurs in young men,has a high disability rate,and is a serious threat to the life and health of patients.Biological agents are expensive,and many adverse reactions to hormones,non-steroidal anti-inflammatory drugs,and anti-rheumatic drugs have been recorded.Traditional Chinese medicine can regulate the immunity and anti-inflammatory effects of the disease,and has good clinical effects.To promote the further study of the pathogenesis of ankylosing spondylitis and the development and screening of therapeutic drugs and therapies,in this paper,we summarize the method and mechanisms of modeling of the existing animal model of ankylosing spondylitis and analyze the advantages and disadvantages of the model.To evaluate the agreements between Chinese and Western medicine clinical characteristics,we compare the characteristics of Chinese and Western medical syndromes of the animal model.Building an animal model of ankylosing spondylitis with a higher degree of consistency between traditional Chinese and Western medicine is the key to innovative research into traditional Chinese medicine method of treating ankylosing spondylitis.To lay the foundation for research into traditional Chinese medicines and acupuncture for ankylosing spondylitis,this paper analyzes the degree of concurrence between the Chinese and Western medicine clinical characteristics of animal models.

ankylosing spondylitisanimal modelclinical syndrome characteristics

张芳之、苗芙蕊、范郁山、贺煜竣

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广西中医药大学针灸推拿学院,南宁 530001

强直性脊柱 动物模型 临床病症特点

国家自然科学基金广西壮族自治区中医药管理局中医药人才队伍建设专项范郁山广西名中医传承工作室广西中医药大学博士科研启动基金项目广西研究生教育创新计划项目

822609832023017-05-072023BS017YCBZ2023149

2024

中国比较医学杂志
中国实验动物学会,中国医学科学院医学实验动物研究所

中国比较医学杂志

CSTPCD北大核心
影响因子:0.473
ISSN:1671-7856
年,卷(期):2024.34(8)