信号转导和转录激活因子3(signal transducer and activator of transcription 3，STAT3)可调控细胞转化、增殖、存活等多种基因的表达，已成为癌症治疗的重要靶点。越来越多的研究表明，STAT3的异常激活在糖尿病肾病(diabetic kidney disease，DKD)发生发展中发挥着重要作用。因此，本文将重点介绍STAT3在DKD中的治疗潜力，包括STAT3的结构、活性调控机制、在DKD中的异常激活作用机制以及研究现状的整理总结，以期为DKD发病机制研究以及新药研发提供参考。
Research progress in the mechanism of STAT3 in diabetic kidney disease
Signal transducer and activator of transcription 3(STAT3)is known to modulate the expression of genes related to cell transformation,proliferation,and survival,making it a significant target for cancer therapy.Recent research has also highlighted the crucial involvement of aberrant STAT3 activation in the pathogenesis of diabetic kidney disease(DKD).Accordingly,this article focuses on the therapeutic potential of targeting STAT3 in DKD.The structure of STAT3,its mechanisms of activity regulation,mechanisms of abnormal STAT3 activation in DKD,and a summary of the current research is provided.The review aims provide a reference for research into the pathogenesis of DKD and the development of new drugs.
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