Overview of traditional Chinese medicine's role in regulating the mechanism of regulatory cell death in vascular dementia
李慧 1董新刚 2李伟峰1
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作者信息
1. 河南中医药大学康复医学院,郑州 450046
2. 河南中医药大学第一附属医院,郑州 450046
折叠
摘要
血管性痴呆(vascular dementia,VD)是一种由大脑损伤所引起的神经退行性疾病,其发病机制尚未完全明确.现有大量研究表明,凋亡、焦亡、自噬、铁死亡以及铜死亡等调节性细胞死亡(regulated all death,RCD)的发生机制与VD病理机制有关.因此,明确这些细胞死亡发生机制与VD病理机制之间的联系,阐述RCD在疾病发病机制中的作用,对于VD的防治具有重要意义.本文就5种RCD的发生机制在VD中的作用展开综述,并总结了近几年中药通过干预这几种RCD防治VD的研究进展,以期为进一步挖掘治疗VD的潜在靶点及中药新药的开发提供参考.
Abstract
Vascular dementia(VD)is a neurodegenerative disease caused by brain injury.Research on the processes leading to its occurrence is lacking depth.In recent years,it has been proposed that regulatory cell death(RCD)mechanisms,including apoptosis,pyroptosis,autophagy,ferroptosis,and cuproptosis,are related to the pathological mechanisms of VD.Therefore,studies aiming to explain the links between the mechanisms of regulatory death and the pathology of VD would be beneficial to our understanding of VD.This article provides a review of the roles of five mechanisms of RCD in VD and summarizes the recent progress made in researching the treatment of VD with traditional Chinese medicine,providing a resource for the development of new traditional Chinese medicine drugs.
关键词
血管性痴呆/调节性细胞死亡/串扰机制/铁死亡/铜死亡/中药防治
Key words
vascular dementia/regulatory cell death/crosstalk/ferroptosis/cuproptosis/traditional Chinese medicine prevention and treatment
维普
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