中国比较医学杂志2024,Vol.34Issue(9) :172-178.DOI:10.3969/j.issn.1671-7856.2024.09.020

基于氧化应激探讨斑马鱼在心血管疾病的应用及研究进展

Research progress on the role of oxidative stress in cardiovascular disease in zebrafish

费添添 梁腾云 曹盼夏 孟雪 吴鸿
中国比较医学杂志2024,Vol.34Issue(9) :172-178.DOI:10.3969/j.issn.1671-7856.2024.09.020

基于氧化应激探讨斑马鱼在心血管疾病的应用及研究进展

Research progress on the role of oxidative stress in cardiovascular disease in zebrafish

费添添 1梁腾云 1曹盼夏 1孟雪 1吴鸿1
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作者信息

  • 1. 河南中医药大学第二临床医学院,郑州 450002
  • 折叠

摘要

心血管疾病已严重威胁人类的生命安全,而氧化应激反应是心血管疾病发生和发展的重要因素.构建可靠的氧化应激动物模型有助于深入研究心血管疾病发病机制和治疗性药物的开发.斑马鱼具有易于繁殖、发育周期短、胚胎透明便于观察、心血管基因背景与人类高度同源等优点,近年来常被用于心血管疾病领域相关研究.本文聚焦于斑马鱼氧化应激模型在心血管疾病领域的应用与相关研究进展,为其在心血管疾病相关研究中的进一步应用提供参考.

Abstract

Cardiovascular disease presents a serious threat to human life,and oxidative stress has been identified as an important factor affecting the occurrence and development of cardiovascular disease.The construction of reliable animal models of oxidative stress is important for the in-depth study of the pathogenesis of cardiovascular diseases and the development of therapeutic drugs.Zebrafish have often been for research into cardiovascular diseases,due to their advantages of easy reproduction,a short developmental cycle,transparent embryos for easy observation,and a highly homologous cardiovascular genetic background with humans.In this paper,we review the application of the zebrafish oxidative stress model in cardiovascular disease and related research progress,to provide a reference for its further application in cardiovascular disease-related research.

关键词

氧化应激/斑马鱼/心血管疾病

Key words

oxidative stress/zebrafish/cardiovascular disease

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基金项目

河南省特色学科中医学学科建设项目(STG-ZYX05-202142)

河南中医药科学研究专项(2021JDZX2025)

河南中医药大学2023年度研究生科研创新能力提升计划(2023KYCX045)

出版年

2024
中国比较医学杂志
中国实验动物学会,中国医学科学院医学实验动物研究所

中国比较医学杂志

CSTPCD北大核心
影响因子:0.473
ISSN:1671-7856
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