Research progress in the mechanism and role of key signaling pathways of the peroxisome proliferator-activated receptor γ gene in osteoarthritis
Osteoarthritis(OA)is a chronic degenerative disease with a high incidence rate among middle-aged and elderly people.It can cause joint pain,deformity,and functional impairment,leading to a heavy burden on patients and their families.Peroxisome proliferator-activated receptor γ(PPARγ)is a recently discovered ligand-dependent transcriptional regulatory factor that can regulate fat and carbohydrate metabolism,inflammation,and immune processes.Research has shown that the PPARγ gene plays an important role in OA cartilage degeneration,synovitis inflammation,and adipose lesions,and can affect OA progression through signaling pathways such as the AMP-activated protein kinase,Wnt,and sirtuin 1 pathways.This review focuses on the role and mechanism of the PPARγ gene in OA,in relation to joint-related tissues and key signaling pathways.
PPARγ geneosteoarthritisjoint tissuessignaling pathwaymechanism of action
万方数据
维普
