养肝益水颗粒成型工艺
Molding Techology of Yanggan Yishui Granule
王丽 1高家荣 2韩燕全 3魏良兵 3吴溪 2吴亦菲 1季文博1
作者信息
- 1. 安徽中医学院药学院,合肥230031
- 2. 安徽中医学院药学院,合肥230031;安徽中医学院第一附属医院,国家中医药管理局中药制剂三级实验室,合肥230031
- 3. 安徽中医学院第一附属医院,国家中医药管理局中药制剂三级实验室,合肥230031
- 折叠
摘要
目的:研究养肝益水颗粒的成型工艺.方法:以吸湿率为指标考察辅料的种类及配比；以颗粒吸湿率和成型率为指标,筛选最佳成型工艺条件,并考察颗粒的休止角,吸湿率,临界相对湿度.结果:以可溶性淀粉-β-环糊精2∶1为最佳辅料及配比,浸膏粉与辅料按1∶1的比例混匀,加入60％乙醇,60℃下干燥,制得颗粒流动性好,临界相对湿度约为68％.结论:该成型工艺合理、可行,为大生产提供了科学依据.
Abstract
Objective: To study on molding technology of Yanggan Yishui granule. Method: Category and ratio of accessories were investigated by taking moisture absorption percentage as index; Optimum molding technology were screened by taking moisture absorption percentage and molding rate of granule as indexes, and investigated angle of repose, moisture absorption percentage and critical relative humidity of granule. Result: Optimal ratio of soluble starch to β-Cyclodextrin was 2:1, extract powder and adjuvants were mixed evenly in proportion of 1: 1 ,60% alcohol was added, dried at 60 ℃ . Granules had a good fluidity,critical relative humidity was about 68% . Conclusion: This molding technology was reasonable, feasible and could provide scientific basis for production.
关键词
养肝益水颗粒/成型工艺/吸湿性/正交试验/临界相对湿度Key words
Yanggan Yishui granule/molding technology/hygroscopicity/orthogonal test/critical relative humidity引用本文复制引用
基金项目
安徽省卫生厅医药科研课题(2009zy19)
出版年
2012
国家科技期刊平台
NSTL
维普
万方数据