首页|丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用

丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用

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目的:考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用.方法:用改良Franz扩散池法,以氮酮为阳性对照,不含促渗剂的磷酸川芎嗪贴剂为阴性对照,考察含3％,5％,7％,10％的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果,采用HPLC测定磷酸川芎嗪的含量.结果:4种质量分数的丁香油对磷酸川芎嗪12h平均累积渗透量(Q12)分别为3.030,4.066,1.845,1.205 mg·cm-2;其12h时增渗倍数分别为1.54,2.06,0.96,0.62.与阴性对照组的Q12比较,5％丁香油与3％丁香油促渗作用显著.结论:3％,5％的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量,且促渗效果好.
Percutaneous Enhancement Function of Volatile Oil from Eugenia caryophyllata on Ligustrazine Phospate Patch
Objective; To investigate percutaneous penetration effect of different concentration of volatile oil from Eugenia caryophyllata on ligustrazine phosphate (LP). Method; Modified Franz diffusion cell method was used, with azone as positive control, LP without penetration enhancers as negative control, penetration effect of 3% , 5% , 7% and 10% volatile oil from E. caryophyllata on LP through mouse skin were investigated, the content of LP was determined by HPLC. Result; Average cumulative permeation volume ( Ql2 ) of the 4 concentrations of volatile oil from E. caryophyllata on LP in 12 h were 3. 030, 4. 066, 1. 845 and 1. 205 mg-cm"2, respectively j and enhancing rates ( ER) in 12 h were 1.54, 2.06, 0.96 and 0.62, respectively. Compared with Qn of negative control group, 5% and 3% volatile oil from E. caryophyllata had significantly enhancing effect. Conclusion; 3% and 5% volatile oil from E. caryophyllata could enhance permeation volume of LP through mouse skin obviously, and had great enhancing effect.

volatile oil from Eugenia caryophyllataligustrazine phosphate patchpercutaneous penetration

罗红梅、马云淑、黄金娥、张贵华、康绍建

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云南中医学院药学院,昆明650500

云南省食品药品检验所,昆明650000

丁香挥发油 磷酸川芎嗪贴剂 经皮渗透

云南省科技计划项目国家自然科学基金

2008CD15230960517

2012

中国实验方剂学杂志
中国中医科学院中药研究所　中国中西医结合学会中药专业委员会

中国实验方剂学杂志

北大核心
影响因子：1.62
ISSN：1005-9903
年,卷(期)：2012.18(11)
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