桑葚多糖抗疲劳作用及其机制
Anti-fatigue Effect and Mechanism of Mulberry Amylose Extracts in Mice
王忠 1厉彦翔 2骆新2
作者信息
- 1. 新疆医科大学医学实验动物中心,乌鲁木齐 830011
- 2. 新疆医科大学药学院药理教研室,乌鲁木齐 830011
- 折叠
摘要
目的:探讨桑葚多糖抗疲劳作用及其机制.方法:雄性SPF级昆明种小鼠224只,随机分为4批,每批56只,分别进行负重游泳、血清尿胆素测定、血乳酸含量测定和肝糖原含量测定.每批动物再随机分为正常对照组、桑葚多糖高、中、低剂量组( 900,300,100 mg·kg-1 ·d-1),连续ig 35 d后,分别测定游泳时间、血清尿胆素含量、血乳酸含量和肝糖原含量.结果:桑葚多糖高剂量组小鼠游泳时间(31.3 ± 15.13)min较正常对照组(7.15 ±2.91 )min明显延长;桑葚多糖高剂量组肝糖原含量(26.23 ±6.08) mg·g-1较正常对照组(18.75 ±3.12)mg·g-1明显增加,血清尿素氮含量(9.66±1.35) mmol·L-1较正常对照组(12.07 ±1.64) mmol· L-1明显减少(P＜0.05).结论:桑葚多糖具有抗疲劳作用.
Abstract
Objective; To explore the anti-fatigue effect and mechanism of polysaccharides from mulberry amylose (MA). Method; A total of 224 Kunming mice were randomly divided into 4 batches, each of which consisted of 4 groups; MA groups at the dosages of low (100 mg ·kg-1) , middle (300 mg ·kg-1 ) and high (900 mg ·kg-1 ) , and the control group. Each mouse was administered once a day for 35 days. After the end of the administration, all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycongen, blood urea nitrogen (BUN) and blood lactic acid. Result; MA at the high dosages could prolong weight-loaded swimming duration (31.3 ±15. 13) min, compared with (7. 15 ±2.91) min. In addition, an increase of hepatic glycongen (26. 23 ±6.08) mg·g-1 , compared with (18.75+3.12) mg ·g-1 and a decline of BUN (9.66 ± 1.35) mmol ·L-1 , compared with (12.07 ± 1.64) mmol ·L-1 were observed in mince administered MA at the high dosages. Conclusion; MA could alleviate physical fatigue.
关键词
桑葚多糖/抗疲劳/机制Key words
mulberry amylose/anti-fatigue effect/mechanism引用本文复制引用
出版年
2012
国家科技期刊平台
NSTL
维普
万方数据