Comparative Study between Effect of Engineering Niuhuang Jiangya Capsule and Artificial Niuhuang Jiangya Capsule on Blood Pressure in Spontaneously Hypertension Rats
Objective:To compare the effect of engineering Niuhuang Jiangya capsule (ENJC) and artificial Niuhuang Jiangya capsule (ANJC) on blood pressure in spontaneously hypertension rats (SHR).Method:SHR were randomly divided into 7 groups in accordance with the systolic blood pressure:model control group,ANJC group and enalapril control group,and ENJC groups (80％,60％,30％,10％ alternated respectively).SHR were given oral drug for 14 d accordingly.ALC-NIBP blood pressure monitoring system was employed to determine blood pressure before drug given and at 5 h,6,10,14 d after drug administration,the blood pressure of 3,7 d after drug application was also monitored.Result:After administration of 5 h,the rats of 80％ ENJC showed significantly (P ＜ 0.05) reduced blood pressure [(SBP (139.25 ± 19.24) mmHg,DBP (105.69 ± 19.18) mmHg],compared with the control group [(SBP (187.2 ± 19.64) mmHg,DBP (123.76 ±18.43) mmHg] On the 6 d of administration 80％ and 60％ ENJC showed significant antihypertensive effect,and the reduced DBP tended to be stable.After taking drug for 14 days,the hypotensive effect of 80％ ENJC was most obvious.ENJC of 80％ and 60％ had significant effect of reducing heart rate.The function is proportional to the dose of ENJC.ANJC did not show the similar effect.Conclusion:Antihypertensive effect of ENJC is better than the original ANJC,with less dose,rapid onset and stonger and lasting effect.
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维普
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