首页|石榴皮总多酚有效部位的化学成分分析

石榴皮总多酚有效部位的化学成分分析

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目的:研究石榴皮总多酚有效部位正丁醇萃取物的化学成分,阐述其抗肿瘤作用的物质基础,为其深度开发利用提供科学依据.方法:采用硅胶柱色谱和反相硅胶柱色谱及制备液相色谱等多种分离技术,从石榴皮总多酚有效部位正丁醇萃取物分离得到了6个单体化合物,根据理化性质和1 H-NMR,13C-NMR等波谱学数据进行结构鉴定.结果:经过结构鉴定,从石榴皮总多酚有效部位正丁醇萃取物中分离得到的6个单体化合物分别为水仙苷(1),1-O-没食子酰基-β-D-葡萄糖(2),2-甲氧基对苯二酚-4-O-葡萄糖苷(3),对羟基苯甲酸葡萄糖酯(4),对香豆酸葡萄糖酯(5),苯乙醇芸香糖苷(6).结论:除化合物2外,其他化合物均为首次从石榴皮中分离得到.
Chemical Compositions of Effective Part in Total Polyphenols From Pomegranate Peel
Objective:To study the chemical constituents from n-butyl alcohol extracts of total polyphenols effective part from pomegranate peel,expound the material foundation of its anti-tumor effect,and provide scientific basis for its development and utilization.Method:Separation techniques such as silica gel column chromatography,reversed-phase silica gel column chromatography and preparation liquid chromatography were used,and 6 monomer compounds were isolated from total polyphenols effective part from pomegranate peel.Their structures were identified according to the physicochemical properties,1H-NMR spectroscopy data and 13C-NMR spectroscopy data.Result:Six monomer compounds were obtained from n-butyl alcohol extracts of total polyphenols effective part from pomegranate peel,and were identified as narcissin (1),1-O-glaloyl-β-D-glucos (2),tachioside (3),p-hydroxybenzoic acid glucose ester (4),coumaric acid glucose ester (5),2-phenylethyl rutinoside (6).Conclusion:All other compounds except compound 2 were isolated from pomegranate peel for the first time.

total polyphenols effective part from pomegranate peelchemical compositionpstructure identification

刘丽、常文、邱慧敏、马桂芝

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新疆医科大学药学院,乌鲁木齐 830054

石榴皮总多酚有效部位 化学成分 结构鉴定

新疆维吾尔自治区科技支撑计划项目

201233135

2016

中国实验方剂学杂志
中国中医科学院中药研究所 中国中西医结合学会中药专业委员会

中国实验方剂学杂志

CSTPCDCSCD北大核心
影响因子:1.62
ISSN:1005-9903
年,卷(期):2016.22(6)
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