Investigation of Powder Properties of Qingdu Xiaoyu Granules and Optimization of Its Granulating Process
Objective:To compare the effects of several pharmaceutic adjuvants (dextrine,amylum solubila,mannitol,microcrystalline cellulose) and their different proportions on the powder properties of Qingdu Xiaoyu granules,and to screen optimum granulating process of this granules.Method:Taking hygroscopicity,mobility,formability and dissolubility as indexes,powder research method was used to screen optimum pharmaceutic adjuvants and their proportions,on this basis,orthogonal test was used to optimize granulating process.Result:The optimum granulating process was mixing the extract with mixed pharmaceutic adjuvants of dextrine-mannitol (1 ∶ 1) at 1 ∶ 2,injecting 85％ ethanol into the mixture with the amount of 13％.Under these conditions,the forming rate,angle of repose,equilibrium moisture absorption rate and dissolution rate of Qingdu Xiaoyu granules were 94.01％,33.72 degree,3.562％ and 97.3％ with RSD of 0.6％,1.6％,1.7％ and 1.9％,respectively.Conclusion:The moisture blocking effect of mannitol is excellent,and the granules prepared by dextrine and mannitol has high mobility,high formability,high dissolubility and low hygroscopicity.In addition,mannitol can effectively improve the taste of the granules.The optimum granulating process is feasible,stable and suitable for industrial production.
NETL
NSTL
万方数据
维普
