人参皂苷类成分治疗肺癌的研究进展
Ginsenosides in Treatment of Lung Cancer:A Review
吕安淇 1施雨峰 1柯佳2
作者信息
- 1. 湖北中医药大学中医学院,武汉 430060
- 2. 湖北省中医院/湖北中医药大学 附属医院/湖北省中医药研究院,武汉 430074
- 折叠
摘要
肺癌是癌症相关死亡的主要原因,具有侵袭性高、转移早、预后差等特点,其发病率和死亡率均居于我国癌症首位.目前肺癌的治疗方法仍然以手术、放疗、化疗及靶向治疗等经典疗法为主,但经典疗法并非适用于所有的肺癌患者,因此需要新的治疗策略及方法来防治肺癌.近年来,人参在抗肺癌研究领域引起了广泛关注,中医药在治疗肺癌方面已积累大量理论基础和实践经验,人参具有大补元气、复脉固脱、补脾益肺、生津养血等功效,人参皂苷是人参的主要活性成分,具有抗癌和抗炎活性.目前国内外研究人员对人参皂苷干预肺癌的机制及药理活性做了大量研究,结果发现人参皂苷类成分可有效抑制肺癌细胞增殖、侵袭、迁移、上皮-间充质转化及血管生成,抑制耐药性、增强化疗敏感性及疗效,促进肺癌细胞凋亡和自噬,调控肿瘤微环境,调节免疫,从而延缓肺癌的发生发展.近几年与此相关的研究成果更新迅速,过去的总结文献未能及时纳入最新研究成果,为众多学者的文献检索带来诸多不便.基于此,该文主要总结了近年来人参皂苷类成分干预肺癌的机制及药理活性,以期为肺癌在药物治疗研究和临床新药研发上提供新的思路,同时也为后续更深入的机制研究提供参考和借鉴.
Abstract
Lung cancer is the leading cause of cancer-related death,characterized by high invasiveness,early metastasis and poor prognosis.It has the highest incidence and mortality rates among cancers in China.Currently,the treatment of lung cancer is still dominated by the classic therapies such as surgery,radiotherapy,chemotherapy and targeted therapy.However,the classic therapies are not suitable for all patients with lung cancer,so new treatment strategies and methods are needed to prevent and treat lung cancer.In recent years,Ginseng Radix et Rhizoma has attracted wide attention in the field of anti-lung cancer research,and traditional Chinese medicine has a substantial theoretical and practical foundation in treating lung cancer.Ginseng Radix et Rhizoma,as a commonly used Chinese herbal medicine,has the functions of replenishing vital Qi,replenishing veins,strengthening the spleen and lung,and nourishing body and blood.The main active components of Ginseng Radix et Rhizoma,known as ginsenosides,exhibit anti-cancer and anti-inflammatory activities.Therefore,the mechanism and pharmacological activity of ginsenosides in the intervention of lung cancer have been extensively studied by researchers worldwide.The results show that ginsenosides can effectively inhibit the proliferation,invasion,migration,epithelial-mesenchymal transition and angiogenesis of lung cancer cells.Additionally,they inhibit drug resistance,enhance chemotherapy sensitivity and efficacy,and promote apoptosis and autophagy of lung cancer cells.Ginsenosides also modulate the tumor microenvironment and regulate immunity,thereby delaying the occurrence and development of lung cancer.The rapid advancements in related research have outpaced previous literature review,creating challenges for scholars seeking the latest information.Based on this,this article summarizes recent findings on the mechanism and pharmacological activities of ginsenosides in lung cancer intervention,aiming to provide new insights for the development of molecular biology,drug treatment research and clinical new drug research in lung cancer.It also provides the reference for further mechanism research.
关键词
人参皂苷类成分/药理活性/肺癌/中医药/作用机制Key words
ginsenosides/pharmacological activity/lung cancer/traditional Chinese medicine/mechanism of action引用本文复制引用
基金项目
国家中医药局凃晋文国医大师传承工作室建设项目(国中医药办人教函[2022]245号)
湖北省公共卫生青年拔尖人才培养计划(鄂卫通[2021]74号)
湖北省自然科学基金(2023AFD173)
国家中医疫病基地项目(湖北)(国中医药医政函[2020]244号)
出版年
2024
国家科技期刊平台
NSTL
万方数据