刍议肠道菌群在"方-证相应"中的作用
Role of Intestinal Microbiota in"Correspondence Between Prescription and Syndrome"
沈俊希 1方乐瑶 1谭周进1
作者信息
摘要
"方-证相应"是中医诊疗客观化的基础,中医诊断客观化是中医现代化的关键,结合现代理论和科技手段探寻"方-证相应"客观指标或生物标志物,有助于明确证候量化指标.肠道存在与疾病证候、方剂疗效相关的特征性微生物种群.肠道菌群对于判断病证形成演变具有重要的指示和鉴别作用,同时也是方剂疗效的重要表征及作用途径.因此,肠道菌群可以作为"方-证相应"客观化的重要生物学指标,"菌-证""菌-方"有关研究内容已较为成熟.在此基础上团队提出"菌-证-方相应"的研究思路和方法,从肠道菌群角度探索"方-证相应"的生物学机制,完整分析了中医泄泻6种证候的"菌-证-方"数据内容,获取不同证候泄泻及相应方剂干预的肠道优势菌群和特征菌群结果,对关键肠道菌群、代谢物与不同证候及方剂干预的相互作用关系进行了关联研究,并探讨了"同病异治"的微生态学机制.研究思路及结果为"菌-证-方相应"学说的建立和应用提供了可能性,也为中医其他病种提供了研究范式."菌-证-方相应"有利于揭示中医证候形成演变及方剂疗效的微观机制,建立基于肠道菌群中医证候客观化诊疗体系,将为中医证候客观化诊疗提供新的方法和思路,推动中医药学现代化和国际化进程.
Abstract
"Correspondence between prescription and syndrome"is the foundation of the objectification of traditional Chinese medicine diagnosis and treatment,and the objectification of traditional Chinese medicine diagnosis is the key to the modernization of traditional Chinese medicine.Combining modern theories and technological means to explore objective indicators or biomarkers of"correspondence between prescription and syndrome"can help clarify quantitative indicators of syndromes.There is a characteristic microbial population in the intestine that is related to syndromes and prescription efficacy.Intestinal microbiota plays an important indicative and discriminative role in determining the formation and evolution of disease patterns and is also an important characterization and pathway of the therapeutic effect of prescriptions.Therefore,intestinal microbiota can serve as an important biological indicator for the objectification of"correspondence between prescription and syndrome",and the research content related to"intestinal microbiota-syndrome"and"intestinal microbiota-prescription"is relatively mature.On this basis,the team proposed a research approach and method of"correspondence among intestinal microbiota,syndrome,and prescription",exploring the biological mechanism of"correspondence between prescription and syndrome"from the perspective of intestinal microbiota.A complete analysis of the"intestinal microbiota-syndrome-prescription"data content of six traditional Chinese medicine diarrhea syndromes was conducted,and the results of intestinal dominant and characteristic microbiota for different syndromes of diarrhea and corresponding formula interventions were obtained.The correlation of key intestinal microbiota and metabolites with the interaction between different syndromes and formula interventions was studied,and the microbiological mechanism of"treating the same disease with different methods"for diarrhea was explored.The research ideas and results provide the possibility for the establishment and application of the theory of"correspondence among intestinal microbiota,syndrome,and prescription"and also provide a research paradigm for other diseases in traditional Chinese medicine."Correspondence among intestinal microbiota,syndrome,and prescription"is conducive to revealing the micro-mechanisms of the formation and evolution of traditional Chinese medicine syndromes and the efficacy of prescriptions.It establishes an objective diagnosis and treatment system for traditional Chinese medicine syndromes based on intestinal microbiota,providing new methods and ideas for the objective diagnosis and treatment of traditional Chinese medicine syndromes and promoting the modernization and internationalization of traditional Chinese medicine.
关键词
证候/方剂/肠道菌群/方证相应/菌证相应/菌方相应/菌证方相应说Key words
syndrome/prescription/intestinal microbiota/correspondence between prescription and syndrome/correspondence between intestinal microbiota and syndrome/correspondence between intestinal microbiota and prescription/correspondence among intestinal microbiota,引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据