软坚散结中药抗肿瘤作用机制研究进展
Anti-tumor Mechanism of Traditional Chinese Medicine with Effect of Softening Hardness and Dissipating Mass:A Review
胡越 1王林枫 1李玥 2刘瑞 1花宝金1
作者信息
- 1. 中国中医科学院广安门医院,北京 100053
- 2. 北京中医药大学研究生院,北京 100029
- 折叠
摘要
恶性肿瘤的全球负担持续增加,发病率和死亡率的上升使其成为全球健康的主要挑战之一.尽管临床上已有多种治疗手段,包括手术切除、放射治疗、化学治疗、靶向治疗和免疫治疗,但这些方法通常会引发严重的不良反应,如组织损伤、免疫功能抑制和多药耐药性,从而对患者的预后和生活质量产生影响.中医药因其低不良反应,多靶点、多系统、多途径发挥治疗作用,在癌症治疗领域显示出积极的治疗潜力.特别是软坚散结类中药,其含有的多种活性成分对肿瘤细胞表现出了优良的抑制作用.这些中药不仅能够直接对肿瘤细胞进行攻击,抑制其增殖和侵袭,还能够通过诱导凋亡、阻断肿瘤相关的信号通路、抑制肿瘤新生血管形成等多种机制发挥作用.此外,中药还能通过调节机体免疫状态、逆转肿瘤细胞的药物耐药性等方式,提高癌症治疗的整体疗效.当前,通过调控细胞内信号通路发挥抗肿瘤作用是中药研究的热点之一.信号通路如信号转导与转录激活子3(STAT3)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)和丝裂原活化蛋白激酶(MAPK)等,在肿瘤的形成和发展中起着关键作用.软坚散结类中药通过影响这些信号通路的活性,调控肿瘤细胞的生长、凋亡和代谢过程,从而实现对肿瘤的治疗效果.基于这些机制,大量实验研究和临床试验已经证明,中医药在抗肿瘤治疗中具有可观的应用前景.为了进一步验证这些研究成果并为中医药的临床应用和新药开发提供依据,对国内外关于软坚散结类中药抗肿瘤作用的研究文献进行系统评述和整合分析,可以更清晰地认识到中药在抗肿瘤治疗中的作用机制,有望推动中医药在全球范围内抗肿瘤治疗的广泛应用,为肿瘤患者带来更多的希望和可能性.
Abstract
The global burden of malignant tumors keeps increasing,and the increased morbidity and mortality make malignant tumors one of the major challenges to global health.Currently,malignant tumors are mainly managed by surgical resection,radiotherapy,chemotherapy,targeted therapy,and immunotherapy,which,however,usually cause serious adverse reactions,such as tissue damage,immune function inhibition,and multidrug resistance,affecting the prognosis and quality of life of the patients.Traditional Chinese medicine with low toxic and side effects and multi-target,multi-system,and multi-pathway therapeutic effects has shown positive therapeutic potential in cancer treatment.In particular,the traditional Chinese medicine with the effects of softening hardness and dissipating mass,which contains a variety of active ingredients,have shown strong inhibitory effects on tumor cells.Such medicine can not only directly attack tumor cells and inhibit their proliferation and invasion but also exert therapeutic effects by inducing apoptosis,blocking tumor-related signaling pathways,and inhibiting tumor angiogenesis.In addition,traditional Chinese medicine can improve the overall efficacy of cancer treatment by regulating the immune status of the body and reversing the drug resistance of tumor cells.Traditional Chinese medicine can exert the anti-tumor effect by regulating intracellular signaling pathways,which is one of the research hotspots in this field.Signaling pathways such as signal transducer and activator of transcription 3(STAT3),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),and mitogen-activated protein kinase(MAPK)play a key role in the formation and development of tumors.Traditional Chinese medicine can regulate the growth,apoptosis,and metabolic process of tumor cells by affecting the activity of these signaling pathways,thus exerting the therapeutic effects on tumors.Based on these mechanisms,a large number of experimental studies and clinical trials have proved that traditional Chinese medicine has broad prospects in anti-tumor treatment.To further verify these research results and provide a basis for the clinical application of traditional Chinese medicine and the development of new drugs,a systematic review and integrated analysis of the research reports on the anti-tumor effect of traditional Chinese medicine was carried out to summarize the anti-tumor mechanisms of traditional Chinese medicine.This review is expected to promote the wide application of traditional Chinese medicine in anti-tumor treatment worldwide and bring more hope and possibility to cancer patients.
关键词
软坚散结/中药/抗肿瘤/作用机制/信号通路/研究进展Key words
softening hardness and dissipating mass/traditional Chinese medicine/anti-tumor/mechanism of action/signaling pathway/research progress引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据