骨质疏松症的发病机制及中医药治疗研究进展
Research Progress on Pathogenesis of Osteoporosis and Intervention of Traditional Chinese Medicine:A Review
章晓云 1曾浩 2黎征鹏 2陈跃平1
作者信息
- 1. 广西中医药大学附属瑞康医院,南宁 530011
- 2. 广西中医药大学研究生学院,南宁 530000
- 折叠
摘要
骨质疏松症(OP)是一种因骨量减少导致骨微结构破坏,骨脆性增加,引起骨相关疾病发生的代谢性疾病,对患者经济及心理均造成沉重的负担.现代医学对OP的发病机制进行了多方面的研究探索,但仍未研究透彻.目前临床上治疗OP主要以抗再吸收药物与合成代谢药物为主,但部分药物长期服用后治疗效果欠佳,且易发生严重不良反应,加之OP需要长期甚至终身治疗,因此寻求高效且安全、经济的药物显得尤为重要.随着疾病治疗模式的改变及近年来对OP研究的深入,中医药治疗OP的优势逐渐显现.笔者通过文献查阅,从激素紊乱、细胞自噬、铁死亡、氧化应激、肠道菌群失调5个方面探析OP的发病机制,并总结中药单体及复方通过调控激素水平、干预细胞自噬、抑制铁死亡、抗氧化应激反应、维持肠道菌群稳态治疗OP的疗效和具体机制,希冀通过多角度为今后临床中医药防治OP提供一定的理论参考与治疗思路.
Abstract
Osteoporosis(OP)is a metabolic disorder characterized by microstructural deterioration of bone and increased bone fragility due to reduced bone mass,which can cause the development of bone-related diseases.This condition imposes significant economic and psychological burdens on patients.While modern medicine has extensively researched the pathogenesis of OP,it remains incompletely understood.Current clinical management primarily relies on anti-resorptive drugs and synthetic metabolic agents.However,long-term use of some medications may yield suboptimal therapeutic outcomes and lead to severe adverse reactions.Given the necessity for prolonged or lifelong treatment for OP,there is a critical need to identify highly effective,safe,and cost-effective pharmaceutical interventions.In light of evolving disease management paradigms and recent advancements in OP research,traditional Chinese medicine has demonstrated emerging advantages in addressing this condition.Through literature review,this study delves into the pathogenesis of OP from five perspectives:hormonal dysregulation,autophagy,ferroptosis,oxidative stress,and intestinal flora alteration.Furthermore,it summarizes the therapeutic efficacy and specific mechanisms of traditional Chinese medicine monomers and compound formulas against OP through regulating hormone levels,interfering with autophagy,inhibiting ferroptosis,counteract oxidative stress,and maintain intestinal flora balance.These multifaceted insights are expected to provide theoretical reference and guide future clinical traditional Chinese medicine approaches for preventing and managing OP.
关键词
骨质疏松症/发病机制/成骨细胞/破骨细胞/骨代谢/中医药Key words
osteoporosis/pathogenesis/osteoblasts/osteoclasts/bone metabolism/traditional Chinese medicine引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据