中药调控Nrf2信号通路干预溃疡性结肠炎的研究进展
Chinese Materia Medica by Regulating Nrf2 Signaling Pathway in Prevention and Treatment of Ulcerative Colitis:A Review
邓亚胜 1习兰花 2范燕萍 1李汶玥 1梁天薇 1黄慧 1李珊 3黄娴 3姚春 3黄国初3
作者信息
- 1. 广西中医药大学,南宁 530200
- 2. 海南省中医院,海口 570100
- 3. 广西中医药大学第一附属医院,南宁 530200
- 折叠
摘要
溃疡性结肠炎(UC)是一种慢性非特异性炎症性肠病,其主要特征为结肠黏膜和黏膜下层的炎症及溃疡形成,其复杂的发病机制涉及免疫异常、氧化应激等多个层面.Nfe212基因编码的核转录因子E,相关因子2(Nrf2)在抗氧化反应中扮演核心角色,其不仅能通过激活血红素加氧酶-1(HO-1)和醌氧化还原酶1(NQO1)等多种抗氧化反应元件,增强谷胱甘肽S-转移酶(GST)和超氧化物歧化酶1(SOD1)等抗氧化酶的活性,有效清除体内累积的活性氧(ROS),减轻氧化应激对肠道黏膜的损害.此外,Nrf2还通过调控免疫反应、细胞凋亡和自噬等通路,减少炎症因子的释放和免疫细胞的浸润,从而缓解肠道炎症,促进受损黏膜的修复与再生.基于此,该文综述了中药在UC防治中通过调控Nrf2信号通路的研究进展,深入探究了 Nrf2的生理作用、激活的分子机制、在UC病理过程中的保护作用,以及中药成分如何通过多途径调控Nrf2信号通路,发挥其潜在的作用机制.这些研究深入揭示了中药通过调节Nrf2信号通路,不仅可有效对抗氧化应激,还能在抗炎、促进自噬、抑制凋亡、保护肠道黏膜屏障及促进肠道黏膜修复等多个方面发挥作用,为UC的多机制治疗提供了新的思路和方法.
Abstract
Ulcerative colitis(UC)is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulceration of the colonic mucosa and submucosa,and its complex pathogenesis involves immune abnormality,oxidative stress and other factors.The nuclear transcription factor E2-related factor 2(Nrf2),encoded by the Nfe212 gene,plays a central role in antioxidant responses.It not only activates various antioxidant response elements such as heme oxygenase-1(HO-1)and quinone oxidoreductase 1(NQO1),but also enhances the activity of glutathione-S-transferase(GST)and superoxide dismutase 1(SOD1),effectively eliminating reactive oxygen species(ROS)accumulated in the body,and mitigating oxidative stress-induced damage to intestinal mucosa.In addition,Nrf2 can reduce the release of inflammatory factors and infiltration of immune cells by regulating immune response,cell apoptosis and autophagy pathways,thereby alleviating intestinal inflammation and promoting the repair and regeneration of damaged mucosa.Based on this,this paper reviews the research progress of Chinese materia medica in the prevention and treatment of UC by modulating the Nrf2 signaling pathway.It deeply explores the physiological role of Nrf2,the molecular mechanism of activation,the protective effect in the pathological process of UC,and how active ingredients in Chinese materia medica regulate the Nrf2 signaling pathway through multiple pathways to exert their potential mechanisms.These studies have revealed in depth that Chinese materia medica can effectively combat oxidative stress by regulating the Nrf2 signaling pathway.It can also play a role in anti-inflammatory,promoting autophagy,inhibiting apoptosis,protecting the intestinal mucosal barrier,and promoting intestinal mucosal repair,providing new ideas and methods for the multi-faceted treatment of UC.
关键词
中医药/溃疡性结肠炎/核转录因子E,相关因子2(Nrf2)信号通路/氧化应激/作用机制/研究进展Key words
traditional Chinese medicine/ulcerative colitis/nuclear transcription factor E2-related factor 2(Nrf2)signaling pathway/oxidative stress/mechanism/research progress引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据