基于"正邪"理论探讨病毒性肺炎"免疫-炎症"机制及中医药治疗
Immunity-inflammation Mechanism of Viral Pneumonia and Traditional Chinese Medicine Treatment Based on Theory of Healthy Qi and Pathogenic Qi
栾哲宇 1王晗笑 1彭鑫 1张益豪 1李云辉 2封继宏2
作者信息
- 1. 天津中医药大学,天津 301617
- 2. 天津中医药大学第二附属医院,天津 300250
- 折叠
摘要
病毒性肺炎是病毒感染侵袭肺实质、间质而引起肺部炎症的感染性疾病,发病率逐年升高.中医药对于病毒性肺炎的治疗不囿于病原体类型,多成分、多靶点、整体性地对不同呼吸道病毒所致肺炎的核心病机进行治疗,不良反应少,具有明显优势.基于中医正邪理论,正邪斗争与免疫-炎症失衡贯穿病毒性肺炎的整个疾病过程,不同疾病阶段的免疫-炎症状态反映出不同的正邪关系.免疫功能低下致正气亏虚造成病毒性肺炎感染,正邪交争致免疫-炎症紊乱造成病毒性肺炎发病,炎症损伤致痰瘀内毒续生造成病毒性肺炎进展,炎症风暴引发免疫耗竭致邪盛正衰造成病毒性肺炎恶化,此外病毒性肺炎愈后长期遗留免疫失衡及微炎症呈现正虚邪恋状态.正虚邪毒作为不同呼吸道病毒所致肺炎的共同核心病机,临床治疗当扶正与祛邪并重,帮助机体恢复正邪平衡与免疫-炎症稳态,促进病毒性肺炎患者康复.该文从中医正邪理论出发,总结病毒性肺炎不同阶段免疫-炎症机制,探讨扶正祛邪法在病毒性肺炎中的应用,旨在深入挖掘中医正邪理论在病毒性肺炎中的科学内涵,为临床使用扶正祛邪法辅助治疗病毒性肺炎提供思路与参考.
Abstract
Viral pneumonia is an infectious disease caused by virus invading the lung parenchyma and interstitial tissue and causing lung inflammation,with the incidence rising year by year.Traditional Chinese medicine(TCM)can treat viral pneumonia in a multi-component,multi-target,and holistic manner by targeting the core pathogenesis of pneumonia caused by different respiratory viruses,demonstrating minimal side effects and significant advantages.According to the theory of healthy Qi and pathogenic Qi in TCM,the struggle between healthy Qi and pathogenic Qi and the imbalance between immunity and inflammation run through the entire process of viral pneumonia,and the immunity-inflammation status at different stages of the disease reflects different relationships between healthy Qi and pathogenic Qi.Immune dysfunction leads to the deficiency of healthy Qi,causing viral infections.The struggle between healthy Qi and pathogenic Qi causes immunity-inflammation imbalance,leading to the onset of viral pneumonia.Inflammatory damage causes persistent accumulation of phlegm and stasis,leading to the progression of viral pneumonia.The cytokine storm causes immunodepletion,leading to the excess of pathogenic Qi and diminution of healthy Qi and the deterioration of viral pneumonia.After the recovery from viral pneumonia,there is a long-term imbalance between immunity and micro-inflammation,which results in healthy Qi deficiency and pathogenic Qi lingering.Healthy Qi deficiency and pathogenic Qi excess act as common core causes of pneumonia caused by different respiratory viruses.Clinical treatment should emphasize both replenishing healthy Qi and eliminating pathogenic Qi,helping to restore the balance between healthy Qi and pathogenic Qi as well as between immunity and inflammation,thus promoting the recovery of patients from viral pneumonia.According to the TCM theory of healthy Qi and pathogenic Qi,this article summarizes the immunity-inflammation mechanisms at different stages of viral pneumonia,and explores the application of the method of replenishing healthy Qi and eliminating pathogenic Qi in viral pneumonia.The aim is to probe into the scientific connotation of the TCM theory of healthy Qi and pathogenic Qi in viral pneumonia and provide ideas for the clinical application of the method of replenishing healthy Qi and eliminating pathogenic Qi to assist in the treatment of viral pneumonia.
关键词
病毒性肺炎/正邪/免疫-炎症/扶正祛邪/中医药Key words
viral pneumonia/healthy Qi and pathogenic Qi/immunity-inflammation/replenishing healthy Qi and eliminating pathogenic Qi/traditional Chinese medicine引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据