Treatment of Diabetic Kidney Disease with Active Ingredients of Astragali Radix Based on Inflammation:A Review
Diabetic kidney disease(DKD)is one of the common microvascular complications of diabetes mellitus(DM)and a primary cause of chronic kidney disease(CKD)and end-stage renal disease(ESRD).Inflammation is currently a hot topic in exploring the pathogenesis of DKD.Macrophages,T cells,interleukins,tumor necrosis factor,NOD-like receptor protein 3(NLRP3)inflammasome,Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway,and nuclear factor-kappa B(NF-κB)-related signaling pathway all play a role in regulating the inflammation of DKD and accelerating its progression.Astragali Radix,a Chinese herbal medicine,is widely used in the treatment of DKD and possesses strong anti-inflammatory effects.Studies have revealed that active ingredients of Astragali Radix,including polysaccharides,astragaloside Ⅳ,total flavonoids,calycosin,and quercetin,can regulate multiple signaling pathways to ameliorate the microinflammatory state and alleviate kidney damage,thereby slowing down the progression of DKD.This article systematically reviews the factors influencing the inflammation in DKD and analyzes recent research findings and mechanisms concerning active ingredients of Astragali Radix in the management of DKD inflammation,aiming to offer novel insights and directions for the prevention,treatment,and research of DKD.
diabetic kidney diseaseinflammationactive ingredients ofAstragali Radixmechanism research
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