Traditional Chinese Medicine Treats Sepsis by Regulating PI3K/Akt Pathway:A Review
Sepsis is a systemic inflammatory response syndrome caused by the invasion of pathogenic microorganisms such as bacteria.In addition to the manifestations of systemic inflammatory response syndrome and primary infection lesions,critical cases often have manifestations of organ hypoperfusion.The morbidity and mortality of sepsis have remained high in recent years,which seriously affect the quality of life of the patients.The pathogenesis of sepsis is complicated,in which uncontrollable inflammation is a key mechanism.The phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway plays a key role in mediating inflammation in sepsis.The available therapies of sepsis mainly include resuscitation,anti-infection,vasoactive drugs,intensive insulin therapy,and organ support,which show limited effects of reducing the mortality.Therefore,finding new therapeutic drugs is a key problem to be solved in the clinical treatment of sepsis.In recent years,studies have shown that traditional Chinese medicine(TCM)can regulate the PI3K/Akt pathway via multiple pathways,multiple effects,and multiple targets to inhibit inflammation and curb the occurrence and development of sepsis,which has gradually become a hot spot in the prevention and treatment of sepsis.Moreover,studies have suggested that TCM has unique advantages in the treatment of sepsis.TCM can regulate the PI3K/Akt signaling pathway to inhibit inflammation,reduce oxidative stress,and control apoptosis in the prevention and treatment of sepsis.Despite the research progress,a systematic review remains to be performed regarding the TCM treatment of sepsis by regulating the PI3K/Akt signaling pathway.After reviewing relevant papers published in recent years,this study systematically summarizes the relationship between PI3K/Akt pathway and sepsis and the role of TCM in the treatment of sepsis,aiming to provide new ideas for the potential treatment of sepsis and the development of new drugs.
sepsisphosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathwaytraditional Chinese medicinereview
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