摘要
目的 探讨Corin联合子宫动脉RI、PI、S/D值对子痫前期的预测价值.方法 选择2015年12月—2020年9月在兰州大学第二医院行常规产检并诊断为子痫前期的孕妇(55例);同期单胎健康孕妇为对照组(55例).ELISA方法测定孕中期(16～24周),孕晚期(28～32周)血清Corin浓度,超声多普勒检测孕中、晚期子宫动脉RI、PI、S/D值.ROC曲线分析上述指标联合对妊娠中晚期孕妇发生子痫前期的预测价值.结果 孕中、晚期血清Corin含量联合子宫动脉PI、RI、S/D值得到的联合预测概率作ROC曲线下面积分别为0.850、0.862,敏感度分别为80.1％、88.3％,特异度分别为82.6％、83.9％,明显高于各指标单独使用的预测作用.结论 联合检测孕妇血清Corin可提高子宫动脉血流动力参数对子痫前期的预测价值.
Abstract
Objective To investigate the predictive value of Corin combined with RI,PI,S/D of uterine artery for preeclampsia.Methods 55 healthy pregnant women and 55 women with preeclampsia(PE)who underwent routine prenatal examination were enrolled from December 2015 to September 2020 in Lanzhou University Second Hospital.Serum Corin levels were measured by Elisa during the second trimester(16-24 weeks)and the third trimester(28-32 weeks).The uterine artery RI,PI,S/D were measured by Doppler ultrasound.The predictive value of combined detection of these indexes on the occurrence of pre-eclampsia was analyzed by ROC curve.Results The combined prediction probability of serum Corin content combined with uterine artery PI,RI and S/D values in the second and third trimesters was 0.850 and 0.862,respectively in AUC,the sensitivity was 80.1％,88.3％,the specificity was 82.6％,83.9％,which is significantly higher than the predictive effect of each indicator alone.Conclusion Combined detection of serum Corin in pregnant women can improve the predictive value of uterine artery hemodynamic parameters for preeclampsia.
基金项目
甘肃省陇原青年创新创业人才个人项目(2022LQGR47)
NETL
NSTL
维普
万方数据