拮抗剂方案鲜胚移植结合选择性单胚移植的临床效果观察
Clinical observation of the combined effect of antagonist protocol with fresh embryo transfer and selective single embryo transfer
黄园斐 1罗龙丹 1丁书芳 1高晶 2何柏松 1叶天民1
作者信息
- 1. 518053,香港大学深圳医院生殖医学中心
- 2. 中山大学附属第三医院生殖医学中心
- 折叠
摘要
目的 探讨以单胚胎移植为主的体外受精-胚胎移植(IVF-ET)治疗策略结局与应用的可行性.方法 选取2015年10月至2020年12月于本院生殖中心接受IVF-ET治疗的不孕患者1 096例进行回顾性分析.采用拮抗剂方案促排卵新鲜胚胎移植治疗,根据其移植胚胎数及胚胎发育时间分为A、B、C三组,A组第二天胚胎单胚胎移植(n=566),B组第二天胚胎双胚胎移植(n=410),C组第五天胚胎单胚胎移植(n=120),对三组妊娠结局及并发症进行对比分析.结果 A组与B组的临床妊娠率(30.0％vs.33.1％)、活产率(23.6％vs.23.6％)差异均无统计学意义,C组与B组的临床妊娠率(40.0％vs.33.1％)差异无统计学意义,C组与B组的活产率(33.3％vs.23.6％)差异有统计学意义,A组与C组的临床妊娠率(30.0％vs.40.0％)、活产率(23.6％vs.33.3％)差异均有统计学意义.结论 本中心实行的单胚胎移植为主拮抗剂方案是安全有效的策略,双胎移植并未显著提高移植的临床妊娠率及活产妊娠率.
Abstract
Objective To investigate the feasibility of single embryo transfer-based IVF-ET treatment strategy outcomes and applications.Methods A total of 1 096 infertile patients who received IVF-ET treatment in the reproductive center of our hospital from October 2015 to December 2020 were retrospectively analyzed.Ovulation induction fresh embryo transfer treatment was used by antagonist regimen,which was divided into 3 groups according to the number of embryos transferred and the time of embryo development:group A,the next day embryo single embryo transfer(n=566);group B,second day embryo double embryo transfer(n=410);and group C,fifth day embryo single embryo transfer(n=120).Pregnancy outcomes and complications were compared across the three groups.Results There were no significant differences in the clinical pregnancy rate(30.0％vs.33.1％)and live birth rate(23.6％vs.23.6％)between group A and group B.There was no significant difference in the clinical pregnancy rate between group C and group B(40.0％vs.33.1％).There was a statistically significant difference in live birth rate between group C and group B(33.3％vs.23.6％).There were significant differences in the clinical pregnancy rate(30.0％vs.40.0％)and live birth rate(23.6％vs.33.3％)between group A and group C.Conclusion The single embryo transfer as the main antagonist regimen is a safe and effective strategy,and twin transfer does not significantly improve the clinical pregnancy rate and live birth pregnancy rate of transplantation.
关键词
IVF-ET/单胚胎移植/活产妊娠率/临床妊娠率/临床并发症Key words
IVF-ET/single embryo transfer/live birth pregnancy rate/clinical pregnancy rate/clinical complications引用本文复制引用
出版年
2024
NETL
NSTL
万方数据