孕妇血清Hcy水平对婴儿认知-运动发育的影响
Effects of maternal serum Hcy on infant cognitive-motor development
江晓阳 1李辉 2孙瑜 3汪小燕 3杭春梅 4姚雁飞 4杨茜 5邵子瑜6
作者信息
- 1. 237005 安徽六安,安徽医科大学附属六安医院临床营养科;安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
- 2. 合肥市妇女儿童保健中心检验科
- 3. 合肥市妇女儿童保健中心儿童保健科
- 4. 合肥市妇女儿童保健中心孕产保健科
- 5. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系
- 6. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系;合肥市妇女儿童保健中心儿童保健科
- 折叠
摘要
目的 探讨孕妇血清同型半胱氨酸(Hcy)水平与婴儿认知-运动发育的关系.方法 选取2020年4月～5月合肥市区594名孕中期孕妇作为研究对象,孕妇年龄20～35岁,孕周15～20+6周,同时测定孕妇血清Hcy水平.采用年龄与发育进程问卷(ASQ-3)进行评估,主要包括沟通、粗大动作、精细动作、问题解决、个人-社交技能5个方面的发育状况.收集妊娠结局和婴儿6月龄、12月龄认知-运动发育评估结果,采用Pearson相关性分析孕期血清Hcy水平与婴儿认知-运动发育情况的相关性;采用线性回归分析孕期血清Hcy水平与婴儿认知-运动发育水平间关系.结果 单因素分析结果显示,婴儿6月龄ASQ-3各方面得分在出生体重、是否早产、血清Hcy水平的差异均无统计学意义.婴儿12月龄ASQ-3各方面得分在出生体重、是否早产的差异均无统计学意义.不同血清Hcy水平婴儿12月龄婴儿精细动作发育得分比较,差异有统计学意义.相关性分析结果显示,孕期血清Hcy水平与婴儿12月龄精细动作发育得分呈负相关,且差异有统计学意义(r=-0.123,P＜0.05).线性回归分析结果显示,孕期血清Hcy水平对婴儿12月龄精细动作发育得分的影响有统计学差异(β=-0.996,95％CI:-1.83～-0.16,P＜0.05).结论 孕妇血清Hcy水平与婴儿12月龄精细动作发育得分呈负相关,孕期血清Hcy水平升高可能会影响婴儿的认知-运动发育.
Abstract
Objective To explore the relationship between maternal serum homocysteine(Hey)during second trimester and cognitive-motor development of infants.Methods 594 pregnant women(aged 20～35 years)in their second trimester(15-20+6 weeks)in Hefei city were enrolled from April to May 2020.Infants'cognitive-motor development at 6 and 12 months were evaluated through the Age and Developmental Progress Questionnaire(ASQ-3)which five main developmental areas were included,i.e.,communication,gross motor,fine motor,problem-solving,and personal-social skills.Pregnancy outcomes and cognitive-motor assessments were collected,and Pearson correlation was used to analyze the correlation between maternal serum Hcy and infants'cognitive-motor development;linear regression was used to analyze the relationship between maternal serum Hcy and infants'cognitive-motor development levels.Results There is no statistically significant differences for ASQ-3 score at 6 months by birth weight,preterm birth,and serum Hcy.There was no statistically significant differences for ASQ-3 scores at 12 months by birth weight,preterm birth.The difference in infant fine motor development scores at 12 months was statistically significant when comparing infants with serum Hcy.The results of correlation analysis showed that serum Hcy during pregnancy was statistically negatively correlated with infant fine motor development score at 12 months(r=-0.123,P＜0.05).Linear regression analysis showed a statistically significant difference between serum Hcy during pregnancy and infants'fine motor development score at 12 months of age(β=-0.996,95％CI:-1.83 to-0.16,P＜0.05).Conclusion Maternal serum Hcy was negatively correlated with fine motor development scores of infants at 12 months,and elevated serum Hey during pregnancy may affect cognitive-motor development of infants.
关键词
同型半胱氨酸/孕妇/婴儿/认知-运动发育Key words
homocysteine/pregnant woman/infant/cognitive-motor development引用本文复制引用
基金项目
合肥市学术和技术带头人科研活动经费资助项目(2020126)
出版年
2024
NETL
NSTL
万方数据