Research Progress on Major Proteins of African Swine Fever Virus in Viral Propagation
African swine fever(ASF)is an acute,severe and highly contagious porcine disease caused by African swine fever virus(ASFV).ASFV encodes more than 150 structural and non-structural proteins involved in viral entry,replication and morphogenesis.ASFV enters into target cells through clathrin-mediated endocytosis and replicates and assembles in virus factory,which locates in the cytoplasm near the nucleus of the microtubule organization center(MTOC).The mature virus particles are transported to the cell membranes through microtubules and budding.In this study,the functions of key proteins involved in the process of virus entry,replication,assembly and release were analyzed and their potential research values were discussed,which would provide support for further study and development of ASF vaccines and drug targets.
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维普
