Analysis of Changes in Fecal Microbiota in Rabbits with Hepatitis E Virus Infection
This study was designed to investigate the changes in fecal microbiota in rabbits with Hepatitis E virus(HEV)infection.A total of 4 fecal samples of HEV RNA positive rabbits and 4 fecal samples of HEV RNA negative rabbits were collected and divided into P and N groups.The next-generation 16S rDNA sequencing was performed and the data was analyzed for these changes.The results of alpha diversity and PCoA analysis showed a significant difference in the compositions of fecal microbiota between the two groups.Compared with the negative control group,Bacteroidota,Acidobacteriota,Chloroflexi and Muribaculaceae in the HEV infection group significantly increased(P<0.05)while Ruminococcus and Bacteroides significantly decreased(P<0.05).These changes in the composition and abundance of fecal microbiota in rabbits with HEV infection might have the potential significance to become a biomarker of HEV infection.
Hepatitis E virusfecal microbiotahigh-throughput sequencing
国家科技期刊平台
NSTL
万方数据
