Role of host protein SIRT5 in metabolism and disease processes
As a member of the Sirtuins family,SIRT5 is a lysine deacylase dependent on nicotinamide adenine dinucleotide(NAD),with deacetylation,desuccinylation,demalonylation and deglutarylation activities.SIRT5 is an important regulator of cell homeostasis,regulating the activity of proteins involved in different metabolic processes,such as glycolysis,tricarboxylic acid cycle(TCA cycle),fatty acid-β oxidation,and reactive oxygen species(ROS)detoxification.SIRT5 can also act as a tumor activator or suppressor,which plays an important role in neurode-generative diseases.In addition,SIRT5 also plays a key role in the antiviral innate immune response.In this paper,the structure,enzyme activity,biological function and the role of SIRT5 in the disease process were reviewed,so as to comprehensively understand the research status of SIRT5.
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