Effect of sleeve gastrectomy on glucose-metabolism and Ghrelin and IGF-Ⅰ in rats
Sleeve gastrectomy,also known as gastric reduction surgery,is mainly used for weight loss and the treatment of type 2 diabetes.This study aimed to investigate the effect of sleeve gastrectomy on glucose-metabolism and growth-regulating hormones Ghrelin and IGF-Ⅰ in rats.In this study,the SD rats in the experimental group underwent sleeve gastrectomy,and the control group underwent sham surgery.On the 7th postoperative day,the plasma contents of ghrelin,IGF-Ⅰ and glucose and the mRNA expression level of IGF-Ⅰ,IGFBP-3,GHS-R and GH-R were measured in organ tissue samples.The levels of ghrelin and IGF-Ⅰ in plasma of experimental group after surgery were significantly lower than those of control group(P＜0.01),and the expression levels of IGF-Ⅰ and GH-R mRNA in the liver,kidney and lung were significantly lower than those of control group(P＜0.01).The mRNA levels of IGFBP-3 in liver andGHS-R in kidney were also significantly lower than those in control group(P＜0.01).In addition,the post-operative blood glucose level of the experimental group decreased significantly(P＜0.01),and the insulin level was significantly lower than that of control group(P＜0.01).The results of this study showed Ghrelin,IGF-Ⅰ and other hormones decreased significantly in rats after sleeve gastrectomy,accompanied by a significant decrease in blood glucose,suggesting that the changes in hormone levels caused by sleeve gastrectomy may affect mediate the regulation of glucose metabolism.
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