猪流行性腹泻病毒主要结构蛋白抗原表位研究进展
Research advances in antigenic epitopes of structural proteins of PEDV
李云涛 1董雅琴 2刘晓君 3曲倩亿 3盖文燕 4张慧 2肖啸 1魏荣2
作者信息
- 1. 云南农业大学动物医学院,云南 昆明 650201
- 2. 中国动物卫生与流行病学中心,山东青岛 266032
- 3. 青岛农业大学,山东青岛 266109
- 4. 山东畜牧兽医职业学院,山东潍坊 261061;甘肃农业大学动物医学院,甘肃兰州 730070
- 折叠
摘要
猪流行性腹泻(PED)是影响养猪业发展的重要疫病之一,其病原为猪流行性腹泻病毒(PEDV).该病毒基因型众多,毒株变异较快,不同基因型毒株交叉保护效果差,增加了疫病的防控难度.对病毒抗原表位的深入研究有助于治疗性抗体、疫苗或诊断试剂的研发.笔者对PEDV主要结构蛋白抗原表位研究现状进行综述,以期为PED药物、疫苗及诊断试剂的研发提供参考.
Abstract
Porcine epidemic diarrhea(PED),caused by porcine epidemic diarrhea virus(PEDV),is a significant disease that causes huge economic losses for the pig production.The virus with its various genotypes,rapid mutation,and lack of cross-protection among different genotypes,presents real diffi-culties for disease prevention and control.More understanding of the viral antigenic epitopes is cru-cial for anti-viral drugs,vaccines and diagnostic reagents development.This review summarizes the current knowledge on PEDV structural protein epitopes and their functions,aiming to provide insights on the development of drugs,vaccines and diagnosis reagents for PED.
关键词
PEDV/结构蛋白/抗原表位Key words
PEDV/structural protein/antigenic epitope引用本文复制引用
出版年
2024