Research progress of natural attenuated vaccine against Pasteurella multocida
Pasteurella multocida is a pathogen that can cause hemorrhagic sepsis or infectious pneumonia in a variety of animals,and is prevalent worldwide.However,the prevention and control methods for animal pasteurellosis are somewhat outdated,with the main use of traditional inactivated and attenuated vaccines developed in the mid-20th century.A recent systematic review on inactivated vaccines for animal pasteurellosis revealed that while they provide high homologous protection,but their immunity duration is short and cross-protect ion between different serotypes is weak.On the other hand,attenuated vaccines offer advantages such as longer immunity duration,strong cross-protection,and lower production costs.Various types of attenuated vaccines have been widely utilized in the history of vaccine development,serving as crucial tools in preventing and controlling human and zoonotic infectious diseases,as well as combating microbial resistance.These vaccines have signifi-cantly decreased the incidence and death rates of various regional and global infectious diseases.Throughout the history of research and application of Pasteurella multocida attenuated vaccines,three main categories have been identified:natural attenuated vaccines,traditional attenuated vaccines,and genetically engineered attenuated vaccines.This article reviews the natural attenuated vaccines,in order to provide a theoretical basis and new ideas for the research and development of new attenuated vaccines for pasteurellosis in livestock and poultry.
国家科技期刊平台
NSTL
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