机械力刺激下牙周膜细胞对破骨细胞调控作用研究进展
Research advances in the effect of periodontal ligament cells in regulating osteoclasts under mechanical stimula-tion
胡晓轩 1丁振江 1陈旭1
作者信息
- 1. 中国医科大学口腔医学院·附属口腔医院儿童口腔科,辽宁省口腔疾病重点实验室,辽宁 沈阳 110002
- 折叠
摘要
牙周膜细胞(periodontal ligament cells,PDLCs)是牙周膜中常见的细胞,在维持牙周组织形态与功能完整性、分散牙周组织受力及维持牙周组织稳态中发挥重要作用;此外,PDLCs也是一种独特的力学感受细胞,可将其受到的机械力信号转换为生物学信号,进而调控下游细胞的生物学行为.破骨细胞(osteoclasts,OCs)是牙根吸收过程中主要的功能细胞,其活性和数量受到PDLCs的调节.文章就机械力刺激下PDLCs对OCs调控作用的研究进展做一阐述,以期为牙根吸收的预防和治疗提供新的思路和方法.
Abstract
Periodontal ligament cells(PDLCs)are common cells in periodontal tissues,and they play important roles in maintaining the morphological and functional integrity,force distribution,and homeostasis protection of periodontal tis-sues.PDLCs are a kind of mechano-sensory cells that can convert mechanical force signals into biological signals,which can regulate the biological behaviors of the downstream cells.Osteoclasts(OCs)are the main functional cells during root resorption,and their viability and quantity are regulated by PDLCs.This paper reviews the research progress on how PDLCs regulate OCs under various mechanical stimulation,and aims to provide new ideas and methods for the preven-tion and treatment of root resorption.
关键词
机械力/牙周膜细胞/破骨细胞/牙根吸收Key words
mechanical force/periodontal ligament cells/osteoclast/root resorption引用本文复制引用
基金项目
辽宁省教育厅科学研究项目(ZF2019031)
出版年
2024
国家科技期刊平台
NSTL
万方数据